Project Grant R21AG100967
- Federal Grant Award Summary Vanderbilt University received a $482,800 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded February 1, 2026, with completion targeted for January 31, 2031. The award supports research to understand sphingolipid-dependent remodeling of mitochondria in aging cells. The research project will deliver scientific knowledge regarding mechanisms linking sphingolipid metabolism to mitochondrial dysfunction during aging, employing...
- Federal Project Grant Award Summary Award Overview Vanderbilt University Medical Center received a $242,489 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) on September 2, 2025, for a project period extending through May 31, 2030. The award supports research examining the proteomic signature of dual decline—the concurrent deterioration of gait and cognitive function in older adults—a condition affecting an estimated 10.2% of the aging...
- Federal Project Grant Award Summary Vanderbilt University Medical Center received a $2.2 million Project Grant award from the National Institute on Aging (Aging Research program, CFDA 93.866) effective January 1, 2026, through December 31, 2030. The award supports research investigating mechanistic links between endothelial aging and dementia through development of a novel human induced pluripotent stem cell (iPSC)-derived endothelial cell model. The research deliverables include: (1)...
- Federal Grant Award Summary Vanderbilt University received a $421,250 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective July 1, 2026 through June 30, 2028. The award supports the development and validation of a programmable RNA-based therapeutic platform designed to selectively target and modulate inflammatory reactive astrocytes (IRAs) in Alzheimer's disease (AD) pathology. The research delivers an innovative sensing circuit that...
- Federal Grant Award Summary Vanderbilt University received a $105,627 Project Grant award dated August 5, 2026, from the National Institute on Aging under the Aging Research program (CFDA 93.866) to support research on clonal hematopoiesis caused by mosaic chromosomal alterations (MCAs). This NIH F30 fellowship grant funds investigative work examining how somatic mutations in hematopoietic stem cells contribute to aging-related diseases through clonal expansion of mutated blood cells. The...
- Federal Project Grant Award Summary The University of Virginia received a $522,167 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded August 1, 2025, with a completion date of May 31, 2030. This research project investigates the mechanisms of ribosomal DNA (rDNA) instability during aging, with a focus on understanding how DNA double-strand breaks and genomic instability contribute to cellular aging. The research examines the roles of FOB1 and its...
- Federal Grant Award Summary Funding Agency and Program: National Institute on Aging (NIA), Aging Research Program (CFDA 93.866) Award Details: $519,500 Project Grant awarded May 15, 2026, with completion date April 30, 2028 Products and Services Delivered: Vanderbilt University Medical Center will conduct a two-year research investigation examining epigenetic age acceleration (EAA) and its manifestation across immune cell populations in people living with and without HIV (PWH). The primary...
- Federal Project Grant Award Summary Vanderbilt University Medical Center received a $481,250 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective February 1, 2026 through January 31, 2028. The award supports research directed toward understanding erythropoietin (EPO) competence in the kidney and identifying molecular signatures and markers associated with anemia in elderly populations. The project addresses anemia pathogenesis...
- Federal Grant Award Summary Vanderbilt University Medical Center received a $149,889 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) beginning September 1, 2025, with a completion date of May 31, 2030. The award supports a discovery-focused research initiative to identify mechanistic associations between epigenetic bone age, frailty measures, and bone imaging findings using artificial intelligence (AI) and deep learning (DL) approaches. The...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Columbia University's Health Sciences Division a $690,865 Project Grant effective January 15, 2026, through December 31, 2030, under the Aging Research program (CFDA 93.866). The research project delivers scientific investigation into the mitochondrial and energetic foundations of resilience in human aging, addressing a critical gap in geroscience by linking altered mitochondrial biology—specifically diminished...
Vanderbilt University's Sponsored Programs Administration received a $435,875 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), with an award date of May 15, 2026 and completion date of April 30, 2028. The project, titled "Defining Characteristics of a Resilient Organelle Interactome During Aging," will deliver advanced scientific research and analytical tools focused on understanding cellular aging mechanisms. Using the model organism Caenorhabditis elegans, the research team will apply three-dimensional electron microscopy and artificial intelligence-based image analysis to generate the first detailed map of organelle interactions in aging animals. The project will compare age-dependent changes in animals undergoing lifespan-extending interventions to identify specific features of the organelle "interactome" associated with enhanced resilience during aging. In addition to mapping organelle interactions, Vanderbilt will develop new genetic tools to visualize and manipulate organelle contact sites in living animals, enabling future studies to test how altering subcellular interactions affects aging and disease. The research outputs—including data, tools, and analytical frameworks—will support the broader aging research community's efforts to understand and target the structural underpinnings of aging at the cellular level, contributing to the National Institute on Aging's mission of advancing knowledge regarding aging processes and age-related diseases.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $435.9k | 5/12/26 |