Project Grant R01AG092663
- This Project Grant award of $108,512.00 was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to Oregon Health & Science University (OHSU) on March 6, 2025. The goal of this project is to study the mechanisms underlying neurovascular coupling (NVC) impairment and its contribution to cognitive decline and Alzheimer's disease (AD)-related pathology. Specifically, the researchers will investigate how ischemia-induced increases in the vasoconstrictor endothelin-1...
- Yale University received a $4,705,470 Project Grant award from the National Institutes of Health National Institute on Aging to develop innovative strategies to therapeutically target and image various vascular cellular components to improve understanding of mechanisms leading to dementia. Specifically, the grant will fund proof-of-concept studies focusing on potential cytotoxicity mechanisms related to iron metabolism and reactive oxygen species that may cause microvascular degeneration. The...
- The National Institute on Aging (NIA) awarded a $2,244,471 Project Grant under CFDA 93.866 (Aging Research) to Oregon Health & Science University (OHSU) to develop a first-in-class, CNS-penetrant small molecule agonist for G protein-coupled receptor 39 (GPR39) as a potential treatment for vascular cognitive impairment and dementia (VCID). The 3-year project from September 2023 to August 2026 will use in vitro and in vivo assays to identify lead compounds, determine their safety and...
- The University of Wisconsin System has been awarded a $640,906 Project Grant by the National Institute on Aging (CFDA 93.866 - Aging Research) for the project "Elucidating Cerebrovascular Disease Pathways to Cognitive Decline with Vascular Neuroimaging." The project aims to address the knowledge gap in accurately diagnosing and effectively treating the vascular contributions to cognitive impairment and dementia (VCID), as well as Alzheimer's disease with comorbid cerebrovascular...
- This federal Project Grant award of $286,000 was provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to the University of Oklahoma Health Sciences Center. The project aims to investigate how age-related accumulation of lipid droplets in brain endothelial cells impairs vascular function and contributes to cognitive decline. Specifically, the researchers will knock down a key triglyceride hydrolytic enzyme in brain endothelial cells to evaluate the...
- The National Institute on Aging awarded a $1,931,965 Project Grant (CFDA 93.866 - Aging Research) to the Regenerative Research Foundation, a non-profit organization in Albany, New York. The purpose of this federal grant is to develop and validate a novel human induced pluripotent stem cell (iPSC) model that incorporates cerebral cortical neurons, glia, vascular endothelial cells, and microglia to study cerebrovascular interactions in Alzheimer's disease-related dementias (ADRD). The R61 phase of...
- The National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), has awarded Wake Forest University Health Sciences a $2,421,629 project grant titled "Inspiring Healthy Engagement and Learning for Vascular Dementia (I-HEAL)". The project aims to address gaps in clinical trial participation for vascular contributions to cognitive impairment and dementia (VCID), with a focus on populations in the Stroke Belt region of the Southeastern U.S. The project will run...
- This Project Grant award from the National Institute on Aging (NIA), funded under the Aging Research program (CFDA 93.866), will support research to understand the pathophysiological changes associated with the dual decline in gait and cognition in older adults. The $242,489 award to Vanderbilt University Medical Center will leverage the Vanderbilt Memory and Aging Project cohort to conduct both cross-sectional and longitudinal proteomic analysis to identify the unique plasma proteome signatures...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $471,885 in funding to Oregon Health & Science University (OHSU) to conduct research on the mechanisms underlying brain vascular endothelial cell (BVEC) disruption following vascular brain injury (VBI). The project aims to understand how the glycosaminoglycan hyaluronan (HA) protects BVECs from ferroptosis, a form of programmed cell death, and how elevated expression of the CEMIP...
- This Project Grant award, funded by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866), aims to investigate the impact of SARS-CoV-2 infection on the cerebrovascular system and its role in increasing the risk of Vascular Contributions to Cognitive Impairment and Dementia (VCID). The $2,549,080 award to the University of Illinois will support research over a 4-year period to determine how prior SARS-CoV-2 infection influences blood-brain barrier...
The Project Grant award "Probing Mechanistic Links Between Endothelial Aging and Dementia" is funded by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The $734,957 award to Vanderbilt University Medical Center will leverage human induced pluripotent stem cell-derived endothelial cells (hiPSC-ECs) to study the role of endothelial aging in vascular contributions to cognitive impairment and dementia (VCID). The key objectives are to: 1) passage hiPSC-ECs and identify in vitro aging endpoints, 2) develop a computational multi-scale model to predict aging using multi-omic biosignatures, and 3) select critical biosignature covariates for further mechanistic study. This research aims to address outstanding questions in the field of vascular biology and stem cell aging, with the goal of advancing scientific understanding and identifying potential interventions for dementia.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $735.0k | 12/30/25 |