Project Grant RF1AG095161
- The National Institute on Aging awarded Weill Medical College of Cornell University $1,494,457 under the Aging Research program (CFDA 93.866) on September 15, 2025, to conduct research on Complex III-derived reactive oxygen species in mitochondrial-nuclear crosstalk in Alzheimer's disease and related dementias. The research uses live-cell redox imaging, site-selective mitochondrial reactive oxygen species suppressors, targeted genetic manipulations, molecular profiling, and preclinical testing...
- The National Institute on Aging awarded Weill Medical College of Cornell University $362,342 on March 17, 2026, under the Aging Research program (CFDA 93.866) to conduct research on lysosome homeostasis in aging-related diseases. The research investigates how lysosomes maintain cellular health through homeostatic mechanisms that sense lysosomal stress and either repair damaged lysosomes or generate new ones via transcriptional activation. The study focuses on a mechanism called conjugation of...
- The National Institute on Aging, part of the Department of Health and Human Services National Institutes of Health, awarded Weill Medical College of Cornell University $172,260 on July 1, 2026, under the Aging Research program (CFDA 93.866) to characterize the relationship between electroencephalographic burst-suppression and postoperative delirium in the context of corticothalamic function. The recipient will investigate biomarkers for postoperative delirium, a neurocognitive disturbance...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Weill Medical College of Cornell University a Project Grant totaling $466,125.00 on August 1, 2025, under the Aging Research program (CFDA 93.866) to support a two-year research initiative examining aging in the liver, alcohol consumption, and the retinoic acid pathway. The research will be conducted at the institution's New York facility through July 31, 2027. The project investigates how retinoic acid receptor...
- The National Institute on Aging awarded $128,250 to Weill Medical College of Cornell University on August 5, 2026, under the Aging Research program (CFDA 93.866) to investigate modifiers of human microglia-neuron interplay in tau propagation in vivo. The research employs a human neuron-microglia chimera platform that integrates human neurons, astrocytes, and microglia into the mouse brain to model Alzheimer's disease and frontotemporal dementia pathology. Aim 1 investigates molecular...
- The National Institute on Aging awarded $1,423,796 to Weill Medical College of Cornell University on September 30, 2025, under the Aging Research program (CFDA 93.866) to investigate how cholesterol 25-hydroxylase (CH25H) mediates microglial neuroinflammation and tau toxicity in Alzheimer's disease. The project examines the mechanistic relationship between apolipoprotein E4 and the cGAS-STING-interferon signaling pathway in microglia, focusing on how 25-hydroxycholesterol (25-HC), a bioactive...
- The National Institute on Aging awarded the Scripps Research Institute $2.613 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to investigate a druggable mito-nuclear feedback mechanism that preserves mitochondrial and synaptic function in aging and Alzheimer's disease. The research focuses on elucidating how age and pathological tau destabilize a brain-specific mito-nuclear feedback loop that controls mitochondrial gene expression in response to acetyl-CoA...
- The National Institute on Aging awarded Icahn School of Medicine at Mount Sinai $704,145 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop and apply computational methods for inferring the natural history of Alzheimer's disease from sparse longitudinal molecular and neuroimaging data. The recipient will develop an innovative approach that leverages temporal signal in sparse longitudinal datasets to reconstruct the timeline of Alzheimer's disease progression and...
- The National Institute on Aging awarded Albany Medical College $246,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate inter-organelle dynamics during aging in eukaryotic cells. The work will characterize spatial contexts of inter-organelle communication using C. elegans as a model system to identify organellar signatures that develop during aging and proteostasis decline, establishing a platform to understand how aging impacts organelle interactions and...
- The National Institute on Aging awarded Weill Medical College of Cornell University $218,728 on March 3, 2026, under the Aging Research program (CFDA 93.866) to investigate vulnerable cell populations in aging-induced circadian clock remodeling and disruption. The recipient will conduct high-throughput single-nucleus RNA sequencing of flash-frozen tissues from young and aged mice sampled every four hours over two days in constant darkness. In the first aim, the investigator will profile seven...
The National Institute on Aging awarded Weill Medical College of Cornell University $4.217 million on August 1, 2026, under the Aging Research program (CFDA 93.866) to develop inhibitors of mitochondrial complex III-derived reactive oxygen species for Alzheimer's disease treatment. The recipient will optimize suppressors of electron leak (SELs)—specifically S3QELs (sequels), which selectively suppress reactive oxygen species production by respiratory complex III—as first-in-class therapeutics for dementia. Work involves medicinal chemistry campaigns to improve second-generation S3QELs, structural modeling, pharmacokinetic studies, proteomic and transcriptomic analysis, and efficacy evaluation in disease models. The compounds have demonstrated oral bioavailability, blood-brain barrier penetration, tolerability in animal models over extended treatment periods, reduction of neuroinflammation and neurodegeneration, and lifespan extension in proteinopathy models; however, early analogs require further optimization before disease-model efficacy can be assessed. Period of performance runs through July 31, 2030. Work is performed in New York, New York. The assistance type is a Project Grant, which funds investigator-initiated biomedical research directed toward understanding aging and age-associated diseases. The award obligates $4.217 million.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $4.2m | 7/31/26 |