Project Grant K99AG095211
- The National Institute on Aging awarded $1,423,796 to Weill Medical College of Cornell University on September 30, 2025, under the Aging Research program (CFDA 93.866) to investigate how cholesterol 25-hydroxylase (CH25H) mediates microglial neuroinflammation and tau toxicity in Alzheimer's disease. The project examines the mechanistic relationship between apolipoprotein E4 and the cGAS-STING-interferon signaling pathway in microglia, focusing on how 25-hydroxycholesterol (25-HC), a bioactive...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $529,744 on February 15, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of entorhinal cortex hyperactivity, neuroinflammation, and tau pathology progression in Alzheimer's disease. The research will use two-photon microscopy and chemogenetic manipulation to test three central hypotheses: that entorhinal cortex layer 2 neuronal hyperactivity drives disease...
- The National Institute on Aging awarded New York University $422,297 under the Aging Research program (CFDA 93.866) on February 15, 2026, to investigate mechanisms of dysregulated protein synthesis in human neurons carrying frontotemporal dementia–associated tau mutations. The project uses human induced pluripotent stem cell–derived neurons bearing FTD-associated tau mutations to model how pathogenic tau disrupts protein synthesis. In the first aim, researchers will determine the impact of...
- The National Institute on Aging awarded Rensselaer Polytechnic Institute $698,712 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate apolipoprotein E and reelin interactions in Alzheimer's disease pathology. The research tests the hypothesis that APOE E4 competes with reelin for receptor and heparan sulfate binding, thereby reducing protective reelin signaling and increasing Alzheimer's disease risk. Work includes mechanistic studies using split luciferase assays...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $433,125 will fund a study to investigate the relationship between microglia, neurons, and tau pathology in Alzheimer's disease. The research will utilize a novel model system of microglial co-cultures with hippocampal assembloids derived from patient-derived induced pluripotent stem cell (iPSC) lines with MAPT mutations and healthy controls. The goal is to explore how bidirectional changes...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $100,228 on February 18, 2027, under the Aging Research program (CFDA 93.866) for epigenetic regulation research on microglial dysfunction in Alzheimer's disease. The award funds laboratory research investigating how the protein ARID5B regulates histone modifications that influence microglial identity and function in Alzheimer's disease pathogenesis. The recipient will use CRISPR/Cas9 and CRISPR...
- The National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), awarded a $1,684,689 project grant to Weill Medical College of Cornell University to study the role of microglial lysosomes in the degradation of amyloid-beta, a key pathological feature of Alzheimer's disease. The 3-year project aims to characterize the process of "digestive exophagy" used by microglia to limit the expansion of amyloid-beta plaques, as well as explore the effects of genetic...
- The National Institute on Aging awarded the University of Texas Medical Branch at Galveston $1.788 million on January 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the interplay between microglia and tau oligomer polymorphs in cognitive resilience among individuals with Alzheimer's disease neuropathology who remain cognitively intact. The project tests the hypothesis that brain-derived tau oligomers isolated from cognitively resilient individuals exhibit reduced toxicity...
- The National Institute on Aging awarded the Regenerative Research Foundation $428,175 on February 15, 2026, under the Aging Research program (CFDA 93.866) to develop a human induced pluripotent stem cell (iPSC)-derived three-dimensional vascular microphysiological model for studying cerebral amyloid angiopathy and Alzheimer's disease-related vascular pathology. The recipient will establish a 3D model incorporating microglia and vascular endothelial cells within a microfluidic device to enable...
- The National Institute on Aging, a component of the Department of Health and Human Services, awarded Massachusetts Institute of Technology $596,050 on September 15, 2026, under the Aging Research program (CFDA 93.866) to investigate fuzzy coat dynamics of post-translationally modified tau aggregation. The project examines structural properties of tau, a microtubule-associated protein whose aggregation hallmarks Alzheimer's disease and twenty other neurodegenerative diseases. The research tests...
The National Institute on Aging awarded $128,250 to Weill Medical College of Cornell University on August 5, 2026, under the Aging Research program (CFDA 93.866) to investigate modifiers of human microglia-neuron interplay in tau propagation in vivo. The research employs a human neuron-microglia chimera platform that integrates human neurons, astrocytes, and microglia into the mouse brain to model Alzheimer's disease and frontotemporal dementia pathology. Aim 1 investigates molecular mechanisms of FTD-tau-induced neurodegeneration driven by 4R-P301S tau aggregation in human neurons, testing whether microglia-specific progranulin overexpression rescues neuron loss and examining the neuroprotective role of silencing the long non-coding RNA hnrnpk-as1 via CRISPR-mediated perturbation. Aim 2 introduces amyloid into the chimera to explore amyloid-beta-induced pathological tau propagation and uncover molecular pathways involved in AB-dependent tau spread by comparing seeded and unseeded grafts with or without amyloid. Aim 3 evaluates the modulatory effects of human microglial APOE variants, where APOE4 is associated with elevated Alzheimer's disease risk compared to APOE2 and APOE3. Work is performed in New York, New York, with a period of performance from August 5, 2026, through July 31, 2028. This is a Project Grant, an assistance type under the National Institute on Aging's mission to support biomedical research toward understanding aging, preventing, and treating Alzheimer's disease and related dementias.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $128.3k | 8/4/26 |