Project Grant K23AG095373
- Federal Project Grant Award Summary The National Institute on Aging (CFDA 93.866 – Aging Research) awarded a $577,122 Project Grant to The Trustees of Columbia University in the City of New York, Health Sciences Division, effective February 15, 2026, with completion targeted for January 31, 2031. This clinical research project will deliver a randomized controlled trial investigating electroencephalogram (EEG)-guided anesthesia protocols designed to reduce postoperative delirium (POD) and improve...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Leland Stanford Junior University a $770,000 Project Grant under the Aging Research program (CFDA 93.866) to conduct basic science research addressing postoperative delirium in geriatric populations. Awarded August 15, 2025, with completion scheduled for July 31, 2027, the project will investigate the central role of aldehyde dehydrogenase 2 (ALDH2) in regulating oxidative stress during anesthesia, with...
- Federal Grant Award Summary SLEEP-POD2: Sleep and Circadian Rhythm Biomarkers of Postoperative Neurocognitive Recovery The National Institute on Aging (Aging Research, CFDA 93.866) awarded Massachusetts General Hospital a $868,901 Project Grant on March 1, 2026, with a completion date of January 31, 2031, to conduct a multisite longitudinal cohort study investigating the relationship between perioperative sleep disruption, circadian rhythm disturbances, and postoperative delirium (POD) and...
- Federal Grant Award Summary Weill Medical College of Cornell University received a $216,203 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded June 15, 2026, with completion targeted for March 31, 2029. The award funds a Research and Mentoring Program for the Surgical Care of Older Adults designed to advance surgeon scientist training and improve perioperative outcomes for older adult surgical patients, particularly those from...
- Federal Project Grant Award Summary Weill Medical College of Cornell University received a $268,650 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded August 15, 2025, with a completion date of May 31, 2027. This grant funds investigator-initiated biomedical research directed at understanding the pathogenic mechanisms of Alzheimer's disease (AD) through examination of a novel bone-brain axis. Specifically, the research will...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a Project Grant totaling $423,750 to Weill Medical College of Cornell University on August 15, 2025, under the Aging Research program (CFDA 93.866) to investigate the relationship between preoperative biological age and surgical outcomes in older adults. The research will utilize the UK Biobank cohort (n=502,649) to determine the effect of preoperative biological age on one-year postoperative mortality and evaluate...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Weill Medical College of Cornell University a Project Grant of $212,770.00 (awarded August 15, 2025, with completion by April 30, 2030) under the Aging Research program (CFDA 93.866) to advance research and mentoring initiatives addressing elder mistreatment among persons living with Alzheimer's disease and related dementias (ADRD). The grant supports two primary objectives: mentoring and supporting the next...
- Federal Project Grant Summary Advanced Brain Monitoring, Inc. received a $690,899 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 16, 2025, with completion targeted for May 31, 2027. The award funds the development and validation of a novel mobile electroencephalography (EEG) platform designed to objectively assess neurocognitive deficits associated with post-acute sequelae of COVID-19 (PASC), commonly referred to...
- Federal Project Grant Award Summary Beth Israel Deaconess Medical Center, Inc. (BIDMC) received a $761,496 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded June 15, 2026, with an ultimate completion date of February 28, 2031. The project, titled "From Cells to Society: Using Epigenetics to Understand Brain Vulnerability to Delirium and Cognitive Decline," delivers research services aimed at identifying epigenetic...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Boston University Medical Campus a $1.224 million Project Grant under the Aging Research program (CFDA 93.866) effective August 1, 2025 through April 30, 2030. The award supports multiscale modeling and empirical studies investigating the mechanisms linking normal and pathological brain aging to cognitive decline. The research focuses on progressive myelin dystrophy, synaptic loss, and neuronal hyperexcitability in the...
The National Institute on Aging (NIA) awarded a Project Grant totaling $172,260 to Weill Medical College of Cornell University, effective July 1, 2026 through April 30, 2031, under the Aging Research program (CFDA 93.866). This research initiative investigates the relationship between electroencephalographic burst-suppression (EEG BSP) patterns and postoperative delirium (POD) within the context of corticothalamic function. The principal investigator, an anesthesiologist physician-scientist, will employ hypothesis-driven analytical neuroscience techniques and biostatistical modeling to identify perioperative biomarkers of neurocognitive vulnerability, particularly for older patients and those with pre-existing cognitive impairments including Alzheimer's disease and related dementias. The research tests whether corticothalamic dysregulation increases POD risk and whether BSP in the setting of such dysregulation further modifies this risk by analyzing EEG signal frequency content to assess normal corticothalamic function. This project directly supports NIA's mission to advance biomedical and behavioral research focused on understanding aging processes and preventing Alzheimer's disease and related dementias. The work addresses a significant clinical need, as postoperative delirium confers substantial morbidity and mortality in vulnerable patient populations. By identifying clinically actionable biomarkers with a neurophysiological basis that logically relate to patient outcomes, the research aims to enable treatment modifications that could protect surgical patients from cognitive insults during anesthesia and surgery.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $172.3k | 7/1/26 |