Project Grant R21AG093343
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $159,492 to Weill Medical College of Cornell University to support research focused on identifying and characterizing clonal expansions in aging and aging-related diseases. The key products/services to be delivered under this award include: Developing tools to enable the identification of candidate somatic variants at scale from publicly available data using machine learning approaches. Applying...
- This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 - Alcohol Research Programs) provides $440,566 to Yale University to advance the treatment of alcohol-associated liver disease (ALD). The primary objective is to uncover therapeutic targets and develop effective ALD treatments, with a focus on the methyltransferase-like (METTL) protein family, notably METTL7A, which is highly expressed in ALD patients. The research utilizes cutting-edge technology...
- This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), provides $161,000.00 to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The award supports research to investigate the metabolic basis of sarcopenia, or loss of muscle mass, in alcohol-related liver disease (ALD). The key research objectives include using multi-omics analyses to identify global skeletal muscle...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $550,417 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Texas at Austin. The grant, effective September 1, 2025 through May 31, 2030, supports research to investigate how heavy alcohol exposure in aging individuals leads to impaired microglia function, neurodegeneration, and cognitive deficits. The study aims to determine whether dysregulated neuroimmune and microglia responses are...
- This federal Project Grant award of $701,051 was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273). The grant supports research to investigate the phenotypes and functions of distinct neutrophil populations in patients with severe alcohol-associated hepatitis (AH). Key objectives include: 1) Characterizing the transcriptomic profiles and functional roles of neutrophil subsets in AH using single-cell RNA sequencing; 2)...
- This $385,000 Project Grant awarded by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) will support research at Stanford University to determine how the enzyme aldehyde dehydrogenase 2 (ALDH2) regulates oxidative stress during anesthesia, with a focus on the role of ALDH2 in the context of Alzheimer's disease. The research aims to elucidate the mechanism by which aging-related oxidative stress contributes to prolonged neurological recovery after...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $468,534 to the University of Southern California to examine alcohol consumption as a modifiable risk factor for Alzheimer's disease and related dementias (ADRD). The study aims to delineate the relationship between midlife alcohol consumption and late-life ADRD diagnosis and onset, with a focus on potential sex differences. It will also test the interaction between alcohol consumption...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $438,375 Project Grant under the Alcohol Research Programs (CFDA 93.273) to Cedars-Sinai Medical Center to establish a human liver-on-a-chip model for studying alcohol-associated liver disease (ALD). The 2-year project, starting September 2023, aims to investigate the roles of liver sinusoidal endothelial cells and acetaldehyde metabolism in regulating ethanol-induced liver damage as well as the contribution of fibrotic...
- This $740,075 Project Grant was awarded by the National Institute on Aging (CFDA 93.866 Aging Research) to Weill Medical College of Cornell University on September 15, 2025. The grant supports research to investigate the role of mitochondrial-derived reactive oxygen species (ROS) from Complex III (CIII) in influencing nuclear processes and Alzheimer's disease (AD) pathogenesis. Key research approaches include live-cell redox imaging, genetic manipulations, molecular profiling, and preclinical...
- The National Institute on Aging (NIA) awarded a $442,750 Project Grant (CFDA 93.866) to Duke University to conduct research on using heterochronic (age-mismatched) hepatocyte transplantation to rejuvenate the aged liver. The research aims to understand how transplanting young hepatocytes into old livers, and vice versa, can influence liver function, cellular composition, and the plasma proteome. Key objectives include measuring changes in liver function markers, analyzing the liver's cellular...
This Project Grant award of $466,125, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports research to examine the role of the retinoic acid receptor B (RARB) in protecting the liver from alcohol-induced oxidative stress and accelerated aging in older adults. The key objectives are to: Investigate whether mice with a liver-specific knockout of RARB age more rapidly and if alcohol increases their rate of aging, using spatial transcriptomics and measurements of telomere length, senescence markers, and NAD+/NADH ratio. Define the mechanisms by which RARB protects the liver against oxidative stress induced by alcohol, using primary hepatocytes from young and old wild-type and RARB-knockout mice. The award recipient is the Weill Medical College of Cornell University, a leading academic medical institution in New York focused on biomedical research, medical innovation, and translational science. This research aims to address the challenge of alcohol-associated liver disease in the elderly population, which is projected to grow substantially in the coming decades.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $466.1k | 7/29/25 |