Project Grant R01AG095960
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $308,000 to the Regents of the University of Minnesota to investigate the impact of amyloid-beta 42 (Aβ42) on mitochondrial liquid-liquid phase separation and its effects on mitochondrial dysfunction in Alzheimer's disease. The primary goals are to: (1) Investigate the impact of Aβ42 on mitochondrial ribonucleoprotein granule dynamics in mitochondria; and (2) Use optogenetic control of Aβ42...
- This Project Grant award from the National Institutes of Health (NIH), under the Aging Research program (CFDA 93.866), provides $610,836 to The Broad Institute, Inc. to conduct research on mitonuclear interactions in aging and neurodegenerative diseases like Alzheimer's. The project aims to leverage recent technological advances, including mitochondrial DNA editing and large-scale biobank analyses, to systematically investigate how mitonuclear interactions contribute to aging and...
- This $745,765 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Icahn School of Medicine at Mount Sinai (ISMMS) in New York aims to investigate the effects of Alzheimer's disease (AD) risk genes and aging on human microglia activity and lipid metabolism. The key focus is on understanding how genetic variants associated with increased AD risk or longevity may impact microglia's ability to clear cholesterol/lipid-rich cellular debris, a critical...
- The National Institute on Aging (NIA) awarded a $157,998 Project Grant to The Medical University of South Carolina (MUSC) on July 17, 2025 under the Aging Research federal grant program (CFDA 93.866). The grant supports research to investigate the role of ceramides, a class of bioactive lipids, in regulating mitophagy (the recycling of damaged mitochondria) and its potential therapeutic applications for Alzheimer's disease. The research aims to elucidate the intricate mechanisms by which...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to determine the functional significance of microglial FOXO3 in Alzheimer's disease (AD). The $475,377 award, effective from September 5, 2025 to August 31, 2027, will be used by the awardee, The Trustees of Columbia University in the City of New York, to conduct research on the role of the FOXO3 gene and associated IFN-I signaling pathways in microglial cells and their contribution to AD...
- The National Institute on Aging (NIA) awarded a $842,175 Project Grant under the Aging Research program (CFDA 93.866) to the J. David Gladstone Institutes in San Francisco, CA. The grant, awarded on December 15, 2024, will fund research to explore the role of the NOX2 enzyme in mediating Alzheimer's disease (AD) pathologies, including network hyperactivity, glucose hypometabolism, and accumulation of amyloid-beta and tau proteins. The research aims to assess the therapeutic efficacy of a novel...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $159,492 to Weill Medical College of Cornell University to support research focused on identifying and characterizing clonal expansions in aging and aging-related diseases. The key products/services to be delivered under this award include: Developing tools to enable the identification of candidate somatic variants at scale from publicly available data using machine learning approaches. Applying...
- This Project Grant award for $466,125, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), supports research to analyze the effects of Alzheimer's disease on subcellular transcriptome dynamics and mitonuclear coordination in neuronal soma and projections. The research, conducted by Harvard Medical School, will use a novel technique called Subcellular Timelapse-Seq (STL-Seq) to simultaneously quantify the kinetic rates of transcription, nuclear export, ribosome...
- The National Institute on Aging (NIA) awarded a $442,357 Project Grant under the Aging Research program (CFDA 93.866) to the Research Foundation of the City University of New York (RFCUNY) on December 15, 2024. The grant aims to elucidate the molecular mechanisms that give rise to functionally neurodegenerative microglia, the brain's primary innate immune cells, which have been implicated as major determinants of Alzheimer's disease (AD) risk. The research will leverage novel mouse models and...
- This $6,925,230 Project Grant award from the National Institutes of Health (NIH) National Institute on Aging (CFDA 93.866 - Aging Research) will support a research project at The Trustees of Columbia University in the City of New York to develop a "Multi-Organ Chart of Personalized Susceptibility to Alzheimer's Disease and Aging." The overarching goal is to use large-scale multi-omics, multi-organ biomedical data, advanced artificial intelligence/machine learning, and computational...
This $740,075 Project Grant was awarded by the National Institute on Aging (CFDA 93.866 Aging Research) to Weill Medical College of Cornell University on September 15, 2025. The grant supports research to investigate the role of mitochondrial-derived reactive oxygen species (ROS) from Complex III (CIII) in influencing nuclear processes and Alzheimer's disease (AD) pathogenesis. Key research approaches include live-cell redox imaging, genetic manipulations, molecular profiling, and preclinical testing, with a focus on understanding the regulation and roles of astrocytic mitochondrial ROS in AD-related mechanisms. The research aims to elucidate how CIII-ROS may impact signaling pathways and nuclear functions, with the ultimate goal of providing insights into the complex, interconnected factors underlying AD and related dementias. The project is expected to be completed by June 30, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $740.1k | 9/8/25 |