Project Grant R56DE035224
Award Date 9/19/25
Completion Date 9/18/27
Dollars Obligated $363K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
East Lansing, MI 48824, USA
Similar Awards
- This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $231,492 to develop an in vitro salivary gland Sjogren's syndrome (SS) tissue chip (SSTC) platform. The goal is to use this SSTC platform to investigate the effects of endocrine-disrupting chemicals on the growth and function of salivary gland tissue mimetics. The project will also perform RNA sequencing studies...
- This federal Project Grant award of $468,875, awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research on the age- and sex-related immune mechanisms involved in the salivary gland pathology of Sjögren's disease. The Oklahoma Medical Research Foundation, a non-profit biomedical research institute, will utilize male and female mouse models that spontaneously develop characteristics of...
- The National Institute of Dental and Craniofacial Research (NIDCR) has awarded a $248,750 Project Grant to the ADA Forsyth Institute, Inc. (doing business as The Forsyth Institute) under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program. The purpose of this 2-year grant, which runs from May 1, 2025 to April 30, 2027, is to investigate the role of cellular senescence in salivary gland dysfunction associated with Sjögren's syndrome. The research aims to determine the...
- The federal Project Grant award of $628,965.00 from the National Institute of Dental and Craniofacial Research (CFDA 93.121 - Oral Diseases and Disorders Research) will support research to elucidate how immune cells in the salivary gland niche regulate epithelial cell processes involved in salivary gland development and differentiation. The 5-year research project, awarded on May 1, 2025, will leverage expertise in salivary gland development and niche-epithelial interactions to test the...
- This Project Grant award of $429,000 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will fund research at the University of South Alabama to investigate the use of phosphodiesterase 4 (PDE4) inhibitors as a novel therapeutic approach for treating dry mouth (xerostomia) associated with Sjögren's syndrome. The key objectives are to evaluate how PDE4 inhibition can: 1) potentiate both parasympathetic and...
- This $643,574 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, supports research to determine the therapeutic potential and mechanisms of induced pluripotent stem cell-derived mesenchymal stem/stromal cell (iPSC-MSC) extracellular vesicles in treating dry mouth caused by Sjögren's syndrome or radiation therapy. The project aims to investigate the immunosuppressive and...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $100,676 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to the Icahn School of Medicine at Mount Sinai. The grant, awarded on December 1, 2025, supports research to define the functional contribution of tissue-resident macrophages in regulating salivary gland morphogenesis and development. The project aims to characterize changes in salivary gland niche structures, epithelial...
- This Project Grant award from the National Institutes of Health's (NIH) Trans-NIH Research Support program (CFDA 93.310) provides $432,209 to the University of Wisconsin-Madison to develop microphysiological systems (MPSs) to study Sjögren's disease, a complex autoimmune condition affecting the salivary glands. The goal is to create MPSs that can more faithfully reproduce the in vivo epithelial cell and lymphocyte phenotype and transcriptome, with a focus on understanding how collagen density...
- This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), part of the U.S. Department of Health and Human Services, provides $401,500.00 in funding to Louisiana State University Health Sciences Center-Shreveport to investigate fundamental aspects of the innate immune response to SARS-CoV-2 within the salivary gland. The research, conducted under the NIDCR's Oral Diseases and Disorders Research program (CFDA 93.121), aims to explore molecular...
- The Research Foundation for the State University of New York (RF-SUNY) has been awarded a $300,000 "Trans-NIH Research Support" Project Grant (CFDA 93.310) from the National Institutes of Health (NIH) Office of the Director. The purpose of this 1-year award, effective September 1, 2023, is to investigate the role of cellular senescence and associated inflammatory signaling (the senescence-associated secretory phenotype or SASP) in promoting salivary gland dysfunction in Sjogren's...