The National Institute of Dental and Craniofacial Research (NIDCR) awarded a 5-year, $628,965 Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to the Icahn School of Medicine at Mount Sinai to study how immune cells, specifically macrophages, regulate the development and differentiation of salivary gland cells. The research aims to elucidate the cellular and molecular mechanisms by which macrophages govern salivary gland progenitor dynamics and epithelial cell patterning, with the goal of identifying novel targets for therapeutic strategies to repair, regenerate, and restore salivary gland function. This work leverages the institution's expertise in salivary gland biology, discrete progenitor cell dynamics, and immune-epithelial cell interactions, and will utilize genetic mouse models and transcriptomic approaches to determine how macrophage-derived signals regulate multiple aspects of salivary gland morphogenesis.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $629.0k | 4/18/25 |