Project Grant R21DE033795
Award Date
6/17/25
Completion Date
6/16/27
Dollars Obligated
$402K
Federal Agency
National Institute of Dental and Craniofacial Research
Federal Grant Program
93.121
Assistance Type
Project Grant
Place of Performance
Louisiana, USA
Similar Awards
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $628,965 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the Icahn School of Medicine at Mount Sinai. The grant, with a performance period from May 1, 2025 to April 30, 2030, supports research to elucidate how immune cells in the salivary gland niche regulate epithelial cell processes. The goal is to identify novel immune-specific mediators of salivary gland epithelial cellular...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to investigate the role of tuft cells in salivary gland immunity. The $608,632.33 award will fund a project at The Research Foundation for The State University of New York (RF SUNY) to: 1) Investigate tuft cell distribution and function in salivary gland epithelium; 2) Determine tuft cell chemosensory components;...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $235,500 to Rutgers, The State University of New Jersey to conduct research on identifying alternative receptors for SARS-CoV-2 in oral epithelial cells. The key objectives are to determine the repertoire of SARS-CoV-2 receptors and infection profiles in region-specific oral epithelial cells and tissues from...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $231,492 to develop an in vitro salivary gland Sjogren's syndrome (SS) tissue chip (SSTC) platform. The goal is to use this SSTC platform to investigate the effects of endocrine-disrupting chemicals on the growth and function of salivary gland tissue mimetics. The project will also perform RNA sequencing studies...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $248,750 to the ADA Forsyth Institute, Inc. (doing business as The Forsyth Institute) to investigate the role of cellular senescence in Sjögren's syndrome-associated salivary gland dysfunction. The research aims to determine the impact of cellular senescence on Sjögren's syndrome-related xerostomia (dry mouth) and...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $226,500 Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to The Medical University of South Carolina (MUSC) to conduct research on the role of CD38 signaling in aging-associated immune responses induced by oral bacterial pathogens. The goal is to determine if inhibition of CD38 can attenuate inflammatory bone loss and alleviate aging-associated immune responses caused by oral pathogens like...
This federal Project Grant award of $339,000 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The funding supports research by New York University School of Medicine to investigate the role of autocrine cholinergic signaling in maintaining memory T cell responses in oral squamous cell carcinoma. The research project will be conducted from August 1, 2024 to July 31, 2026. As a leading...
The University of Illinois, under a $581,037 Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support Program (CFDA 93.310), will conduct research to investigate the mechanisms underlying oral post-acute sequelae of COVID-19 (PASC) in minority populations. The key objectives are to: 1) analyze the impact of COVID-19 vaccination on oral PASC indicators and perturbations in oral immune surveillance in Black, Hispanic, and non-Hispanic White cohorts; and 2)...
This Project Grant award of $155,500 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support a comprehensive examination of the oral virome and its interactions with the oral microbiome. The research aims to shed light on the role of viruses in maintaining oral health and contributing to disease, with the goal of illuminating a neglected aspect of the oral microenvironment and potentially...
This $431,750 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) supports research to decipher the mechanisms by which two proteins, AAFLP-1 and AADCUB, regulate the production of exopolysaccharide (PNAG) in the oral bacterium Aggregatibacter actinomycetemcomitans. The research aims to investigate how these two proteins, which are unique to A. actinomycetemcomitans, independently...