Project Grant R01DE032028
- This Project Grant award of $409,960 from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will support the development of a human salivary gland-on-a-chip model at Texas A&M University System Health Science Center. The goal is to establish normal and radiation-damaged salivary gland models that incorporate epithelial cells, endothelial cells, and macrophages to better understand and develop treatments for...
- This $249,000 federal Project Grant, awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to identify cell fate determination processes specific to salivary cell populations in order to advance regenerative therapies. The principal investigator at Rutgers, The State University of New Jersey will conduct studies to understand the normal developmental processes and transcriptional and...
- This $429,000 Project Grant awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will fund research to evaluate the therapeutic potential of targeting phosphodiesterase-4 (PDE4) enzymes as a novel approach to alleviate symptoms and address the underlying causes of salivary gland dysfunction and xerostomia (dry mouth) associated with Sjögren's syndrome. The research will be conducted by the University of...
- This federal Project Grant award of $644,970.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports a research project to investigate immune-epithelial interactions and their impact on restoring salivary gland function after radiation therapy. The long-term goal is to develop mechanisms for restoring salivary gland function in head and neck cancer patients who suffer from chronic xerostomia (dry...
- This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), is supporting research to identify mechanisms that can specifically protect or regenerate salivary glands without benefiting cancer growth after radiation therapy. The $714,711 award to the Icahn School of Medicine at Mount Sinai will fund the development of a scalable gene targeting system to test over 2,600 genetic...
- The National Institute of Dental and Craniofacial Research (NIDCR), through the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded a $406,496 Project Grant to Antixero to develop an extended-duration hyaluronic acid-based oral rinse to provide relief for cancer patients suffering from xerostomia (chronic dry mouth). This innovative solution aims to address the significant unmet need for long-lasting, non-toxic treatments for this debilitating condition, which often...
- This $622,744 Project Grant was awarded by the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program. The grant will fund research to investigate the role of the TRPM2 protein in the development of radiation-induced oral mucositis (RIOM), a common and painful side effect of radiation therapy for head and neck cancer. The research aims to understand how TRPM2 activation contributes to RIOM through the...
- This Project Grant award of $174,418.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to determine the function of TRP-positive trigeminal sensory neurons innervating the submandibular salivary glands. The objective is to understand how this direct sensory innervation of the submandibular glands by trigeminal neurons contributes to the regulation of saliva production and...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $248,750 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to the ADA Forsyth Institute, Inc. (doing business as The Forsyth Institute) located in Cambridge, Massachusetts. The grant will support research to determine the impact of cellular senescence on Sjögren's Syndrome-associated salivary gland dysfunction and salivary gland stem cell activity, with the goal of developing effective...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $491,193 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the University of California, San Diego (UCSD) for the project "Engineering Mucin Analogues to Benefit the Mouth Environment." The project aims to create advanced mucin substitutes that closely emulate the physiological functions of natural salivary mucins, in order to develop enhanced artificial saliva...
This federal Project Grant award, totaling $643,574, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The award was granted to Texas A&M University System Health Science Center to conduct research on the therapeutic mechanisms of induced pluripotent stem cell-derived mesenchymal stem cell (iPSC-MSC) extracellular vesicles for treating dry mouth caused by Sjögren's syndrome or radiation therapy. The research aims to determine the therapeutic potential and underlying mechanisms of these extracellular vesicles in restoring saliva secretion and addressing the debilitating side effects of dry mouth. The project period runs from August 13, 2025, to May 31, 2030, with the goal of providing proof-of-concept and optimization guidance for novel, clinically feasible therapies to address this significant unmet medical need.