This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop microphysiological systems (MPSs) that can recapitulate the complex pathogenesis of Sjogren's disease (SjD), a systemic autoimmune condition affecting the salivary glands. The $196,459 award, effective from August 1, 2025 to July 31, 2027, will support research to investigate how collagen density and the presence of fibroblasts in the microenvironment impact epithelial cell and lymphocyte behavior in SjD. The goal is to create more physiologically relevant MPS models for future therapeutic testing. The research will be conducted by the University of Wisconsin System, leveraging expertise in SjD, salivary gland biology, MPS technologies, and advanced spatial genomics approaches.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $196.5k | 7/23/25 |