This R21 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will support research to determine the impact of cellular senescence on Sjögren's syndrome (SS)-associated salivary gland dysfunction and stem cell activity. The $248,750 project, awarded to the ADA Forsyth Institute, Inc. (The Forsyth Institute) in Cambridge, MA, aims to elucidate the role of cellular senescence in SS-related...
This $231,492 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop the first-ever in vitro Salivary Gland Sjogren's Syndrome Tissue Chip (SSTC) platform. The SSTC will utilize microbubble array technology and the MRL/lpr mouse model to investigate the effects of endocrine-disrupting chemicals on the growth and function of salivary gland tissue mimetics. The project will...
This $115,992 project grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, aims to develop human induced pluripotent stem cell (iPSC)-derived salivary gland organoids (SGOs) with secretory function and well-defined architecture. The key products and services to be delivered include: 1) Programmable differentiation of human iPSCs into salivary gland epithelial progenitors (SGEPs); 2) Engineered...
The Research Foundation For The State University Of New York (RF SUNY) was awarded a $953,119 Project Grant from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) to conduct fundamental research on the regulation and interaction of ceramides in cellular senescence and cell death processes using mammalian cell models. The award, issued on May 1, 2023 with a completion date of April 30, 2027, will support biochemical, chemical biological, and analytical approaches...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121), provides $1,487,286 to the University of Wisconsin-Madison to define how different endotypes of Sjögren's disease modify the immunobiology of salivary gland mesenchymal stromal cells (SG-MSCs). The goal is to elucidate the pathogenic contributions of SG-MSCs in Sjögren's disease, a common autoimmune condition...
The National Institute on Aging (NIA) awarded a $846,358 Project Grant (CFDA 93.866 - Aging Research) to the University of Pittsburgh to build a research platform to assess the senescence-associated secretory phenotype (SASP) in vivo. The goal is to identify the molecular composition of the SASP secretome across different cell types and in response to various senescence-inducing stressors. The researchers will utilize a novel SASP-ER platform that enables conditional tagging and purification...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will provide $260,375 to the University of California, Los Angeles (UCLA) to develop and validate a saliva-based assay for the early detection of Sjögren's disease (SJD) and autoimmune-sicca syndrome (AI-sicca). The key products and services to be delivered include: Acquiring and characterizing clinical cohorts of SJD, AI-sicca,...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $608,632.33 to investigate the role of tuft cells in salivary gland immunity. The key objectives are to: 1) Explore tuft cell distribution and function in salivary gland epithelium; 2) Determine tuft cell chemosensory components; and 3) Assess the effects of tuft cell ablation on salivary gland innate immunity....
This $1,425,000 project grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), will fund research into neuronal senescence and inflammation in Alzheimer's disease. The Salk Institute for Biological Studies will study the interaction between cellular senescence and inflammation in induced neurons derived from Alzheimer's patients and healthy aged controls. Researchers will examine differences in gene expression and epigenetic...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $628,965 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the Icahn School of Medicine at Mount Sinai. The grant aims to elucidate how immune cells, specifically tissue-resident macrophages, regulate the coordinated processes of salivary gland epithelial cell development and differentiation. Using genetic mouse models and transcriptomic approaches, the project will determine how...