This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is providing $409,960.00 to Texas A&M University System Health Science Center to develop a human salivary gland-on-a-chip model. The goal is to create a platform that can faithfully replicate normal salivary gland function as well as model the effects of radiation-induced damage, in order to improve drug development efforts...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop microphysiological systems (MPSs) that can recapitulate the complex pathogenesis of Sjogren's disease (SjD), a systemic autoimmune condition affecting the salivary glands. The $196,459 award, effective from August 1, 2025 to July 31, 2027, will support research to investigate how collagen density and the presence...
This federal Project Grant award of $1,386,899.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The grant aims to define how Sjögren's disease endotypes modify the immunobiology of salivary gland mesenchymal stromal cells, comparing mouse and human models. The research will use JAK inhibitors as immunopharmacological probes to determine the signaling pathways driving maladaptive mouse...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $115,992 to The Research Foundation For The State University Of New York (RF SUNY) to develop human induced pluripotent stem cell (iPSC)-derived salivary gland organoids (SGOs) with secretory function and well-defined architecture. The project aims to utilize engineered viscoelastic hydrogels to optimize the...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $714,711 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the Icahn School of Medicine at Mount Sinai. The 5-year grant, which commenced on July 1, 2025, aims to investigate mechanisms that can specifically protect or regenerate salivary glands without benefiting cancer growth following radiation therapy. The research team developed a scalable gene targeting system to screen over...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), provides $248,750.00 to the ADA Forsyth Institute, Inc. (The Forsyth Institute) to investigate the role of cellular senescence in salivary gland dysfunction associated with Sjögren's syndrome. The research aims to determine the impact of cellular senescence on Sjögren's syndrome-related xerostomia (dry mouth) and...
The federal Project Grant award R00DE032363, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program, will fund research to explore the role of tuft cells in salivary gland immunity. The $608,632.33 award, spanning from Sep 1, 2024 to Mar 31, 2028, will support the following key objectives: (1) investigating tuft cell distribution and function in salivary gland epithelium, (2) determining tuft cell...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), part of the Oral Diseases and Disorders Research program (CFDA 93.121), provides $628,965.00 to the Icahn School of Medicine at Mount Sinai over a 5-year period from May 1, 2025 to April 30, 2030. The funding supports research to elucidate how immune cells, specifically tissue-resident macrophages, regulate the coordinated processes of salivary gland development and differentiation. The...
The federal Project Grant award R21DE033795, totaling $401,500.00, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The award will fund research at Louisiana State University Health Sciences Center-Shreveport to investigate the interaction between SARS-CoV-2 and the salivary gland, including how viral presence and immune responses in this tissue may contribute to COVID-19 pathogenesis. The...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), provides $465,376 to the University of California, Los Angeles (UCLA) to develop a saliva-based electrochemical assay for the early detection of Sjögren's disease (SJD) and its precursor autoimmune-sicca syndrome (AI-sicca). The key objectives are to: 1) detect anti-SSA/Ro52 and anti-SSB/La autoantibodies in the...