Project Grant R43GM150353
Award Date
4/1/23
Completion Date
10/31/24
Dollars Obligated
$700K
Federal Agency
National Institute of General Medical Sciences
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
California, USA
Similar Awards
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $306,860 to Mixedlcmedia LLC to develop a commercialization-ready prototype of an ultra-low flow liquid chromatography (ULF LC) platform.
The goal is to enable deep proteomic profiling of limited biological and clinical samples, such as liquid biopsies, microneedle tissue biopsies, and rare cell isolates. This technology...
This $275,000 Small Business Innovation Research (SBIR) Phase I award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program supports the development of a label-free, high-resolution, high-throughput protein screening platform called Vibrational Spectroscopy with Metasurface Optics (VISMO). The technology aims to enable simultaneous, minute-scale measurement of millions of protein samples, which would dramatically improve the lengthy and costly...
This $350,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of a high-resolution native capillary zone electrophoresis system with inline UV and native mass spectrometry capabilities for characterizing charge variants in biologics.
The funded project aims to address critical challenges in the characterization and quality control of protein therapeutics by...
This $349,566 Project Grant award from the National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports the development of Biosensing Instrument Inc.'s Spotting-Free Nano-Oscillator Array (SFNOA) technology.
The SFNOA system aims to provide high-throughput, label-free quantification of ligand binding kinetics to transmembrane proteins in their native states. Key innovations include the use...
The National Human Genome Research Institute (NHGRI), under the Federal Grant Program "Human Genome Research" (CFDA 93.172), awarded a $407,291 Phase I Small Business Innovation Research (SBIR) grant to Electronic Biosciences, Inc. to develop a nanopore-based protein sequencing platform. The project aims to create a high-accuracy, label-free nanopore reader capable of direct, single-molecule protein sequencing. This novel technology would enable proteome-wide profiling, biomarker...
The National Institute of General Medical Sciences (NIGMS) awarded a $358,862 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to GMJ Technologies, Inc., a minority-owned small business, to develop a microfluidic SDS depletion electrophoresis (SDE) interface. This interface will enable direct coupling of capillary electrophoresis with sodium dodecyl sulfate (CE-SDS) to mass spectrometry for improved characterization and quality control of monoclonal...
This Project Grant award by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $302,417 to Physical Sciences Inc. (PSI) to develop a novel in-line biomanufacturing process analytical technology for real-time monitoring of biomolecules in large-scale bioreactors. PSI will collaborate with the University of Massachusetts Lowell to test and characterize the "virtual chromatographic cytometry"...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $882,600 to Megadalton Solutions, Inc. to develop a high-throughput charge detection mass spectrometry (CD-MS) instrument optimized for characterizing very high mass biological analytes in the megadalton and gigadalton range. The goal is to design and build a 10-detector array CD-MS system that can rapidly analyze...
The National Institute of General Medical Sciences (NIGMS) awarded a $350,000 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Fluidispec LLC in Philadelphia, PA. The grant will fund the development of a new microfluidic/nanofluidic sample preparation platform to improve protein extraction, purification, and denaturation for top-down and bottom-up proteomics workflows. The system aims to enhance the depth of proteome coverage and speed of single-cell proteomics...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program provides $304,196 to Laser Bioanalytics LLC to develop a prototype instrument and techniques for photochemical patterning of lipids in tissue sections. The goal is to enable matrix-assisted laser desorption ionization (MALDI) mass spectrometry structural analysis and imaging of lipids, which are important cellular components involved in...