This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $304,196 to Laser Bioanalytics LLC to develop a prototype instrument and techniques for photochemical patterning of lipids in tissue sections. The goal is to enable more accurate mass spectrometry structural analysis and imaging of lipids, which are important cellular components relevant to disease diagnosis and treatment. The proposed technology will use focused laser beams to drive photochemical reactions in tissue samples that tag lipid double bond locations, facilitating their identification and spatial mapping using matrix-assisted laser desorption ionization (MALDI) mass spectrometry. This project aims to create new capabilities not currently available in commercial mass spectrometry imaging systems, with potential applications in clinical and research laboratories using MALDI mass spectrometry.
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