This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of a high-resolution native capillary zone electrophoresis system with inline UV and native mass spectrometry capabilities for characterizing charge variants in biologics. The $2,297,901 award to GMJ Technologies, Inc., a minority-owned small disadvantaged business, aims to address a critical need in the biopharmaceutical industry for efficient analytical tools to characterize and monitor product variants that could impact the safety and efficacy of protein therapeutics. The proposed innovation combines advanced capillary surface chemistry, a novel optical-electrospray interface, and a sensitive nanoflow electrospray mechanism to enable high-resolution separation and native mass spectrometry detection of charge variants in biologics. This solution is expected to improve the efficiency, precision, and sensitivity of analytical workflows for protein therapeutic research, development, and quality control.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $1.6m | 4/28/25 | ||
| Not listed | $350.0k | 7/5/24 | ||
| Not listed | $350.0k | 7/5/24 |