This Project Grant award from the National Human Genome Research Institute (NHGRI), under the Human Genome Research Federal Grant Program (CFDA 93.172), will support the development of a novel nanopore-based sequencing technology for high-accuracy, single-molecule RNA sequencing. The $347,026 award to Electronic Biosciences, Inc., a small biotechnology company, aims to create a sequencing approach capable of directly and repeatedly sequencing individual RNA molecules, including the ability to...
This Project Grant award from the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health, under the Human Genome Research program (CFDA 93.172), aims to develop a revolutionary DNA sequencing platform that can surpass existing technologies in accuracy and cost. The $384,418 award to Xgenomes Corp. will fund the development of a proof-of-concept "super-resolution single-molecule sequencing" technology that can read short sequence "words"...
The National Human Genome Research Institute (NHGRI), under the Federal Grant Program for Human Genome Research (CFDA 93.172), awarded a $406,500 Project Grant (R41HG013624) to Directseq Biosciences, Inc. to advance next-generation mass spectrometry-based sequencing (NGMS-SEQ) methods for high-throughput direct sequencing and quantitative mapping of RNA modifications.
The key objectives of this project are to: 1) enhance NGMS-SEQ techniques to enable high-throughput direct sequencing of...
The National Human Genome Research Institute (NHGRI), through the Human Genome Research (CFDA 93.172) federal grant program, awarded Survey Genomics, Inc. a $1,887,931 Project Grant to develop and commercialize their CYTOPE-DROP technology. This innovative approach enables high-throughput, spatially-resolved single-cell multiomics analysis, delivering mRNA abundances, protein abundances, and cell locations in a single assay. The proposed activities aim to increase the spatial resolution of...
This federal Project Grant award from the National Human Genome Research Institute (NHGRI), under the Human Genome Research (CFDA 93.172) program, provides $215,088.00 to Directseq Biosciences, Inc. to develop an "exhaustive de novo RNA sequencing method" using next-generation mass spectrometry. The goal is to create a comprehensive approach that can directly identify and sequence every RNA species in a sample, as well as fully profile all RNA modifications, without bias or...
The National Human Genome Research Institute (NHGRI), through the Human Genome Research program (CFDA 93.172), awarded a $1,273,296 Project Grant to the University of Washington to conduct research aimed at integrating the impacts of genetic variation with massively parallel mRNA and protein barcoding. The key products and services to be delivered under this project include:
Conducting high-throughput reporter assays to characterize how variants in coding and untranslated regions impact...
The National Human Genome Research Institute (NHGRI), through its Human Genome Research program (CFDA 93.172), has awarded a $352,929 Project Grant to Ribo-Therapeutics LLC to develop and validate a novel platform for the enrichment and profiling of circular RNAs (circRNAs). The goal is to create a "quick, robust, and unbiased" technology for isolating and characterizing the full repertoire of circRNAs, which have been implicated in various diseases but are challenging to study with...
The National Human Genome Research Institute (NHGRI), under the National Institutes of Health's Human Genome Research (CFDA 93.172) program, awarded a $314,538 Project Grant to Dnali Data Technologies, Inc. in Cary, NC. The funding will support the development of a robust platform technology capable of producing a diverse range of chemically modified DNA products that cannot be ordered from existing vendors. Specifically, the project aims to: 1) create modified DNA products not currently...
This Project Grant award from the National Human Genome Research Institute (NHGRI), under the Human Genome Research federal grant program (CFDA 93.172), supports the development of a novel platform called Helicase-Assisted Continuous Evolution (HACE) for performing multiplexed locus-specific hypermutation within the mammalian genome. The $650,625 award to the Broad Institute, Inc. will be used to apply HACE technology to functionally characterize both non-coding regulatory elements as well as...
The National Human Genome Research Institute (NHGRI), a component of the National Institutes of Health (NIH), awarded a $1,038,898.88 Project Grant (CFDA 93.172 - Human Genome Research) to the Dana-Farber Cancer Institute in Boston, MA. The grant, with a performance period from August 1, 2024 to April 30, 2028, aims to develop novel approaches for integrating single-cell data with genome-wide association studies (GWAS) to identify disease-relevant cell states, fine-map disease variants and...