The National Institute of General Medical Sciences (NIGMS) awarded a $271,495 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Zeteo Tech, Inc. for the development and evaluation of a time-of-flight (TOF) mass spectrometer system with matrix-assisted laser desorption/ionization (MALDI) for fast analysis of antibodies and related macromolecular immune complexes. The project aims to utilize a novel high-temperature superconducting nanowire detector to...
The National Institute of General Medical Sciences (NIGMS) awarded Megadalton Solutions, Inc. a $882,600 Project Grant (CFDA 93.859) to develop a high-throughput Charge Detection Mass Spectrometer (CD-MS) system for rapid analysis of very high mass biological analytes, such as biopharmaceuticals, virus particles, liposomes, and large biomarkers. The project aims to design a multi-detector CD-MS array that can enhance sensitivity and throughput by two orders of magnitude compared to existing...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), supports the development of novel ion chemistry and instrumentation for the characterization of proteins, nucleic acids, and heterogeneous bio-complexes using tandem mass spectrometry. The $1,463,792 award, effective from May 1, 2024 to April 30, 2029, will fund efforts to extend the utility of mass spectrometry and tandem mass...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,469,739 Project Grant (CFDA 93.859 Biomedical Research and Research Training) to the Research Foundation of the City University of New York (RFCUNY) to purchase a TIMSTOF-FLEX MALDI-2 high-resolution mass spectrometer. This novel instrument will support biomedical research projects in twelve laboratories across CUNY and nearby institutions, including investigations into the conformational dynamics of light-sensitive proteins...
The National Institute of General Medical Sciences (NIGMS) awarded a $350,000 Project Grant (CFDA 93.859, Biomedical Research and Research Training) to GMJ Technologies, Inc., a minority-owned small disadvantaged business, to develop a high-resolution native capillary zone electrophoresis system with inline UV and native mass spectrometry capabilities. This innovative analytical technology is designed to enhance the characterization and quality control of protein therapeutics, such as monoclonal...
The National Institute of General Medical Sciences (NIGMS) awarded a $358,862 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to GMJ Technologies, Inc., a minority-owned small business, to develop a microfluidic SDS depletion electrophoresis (SDE) interface. This interface will enable direct coupling of capillary electrophoresis with sodium dodecyl sulfate (CE-SDS) to mass spectrometry for improved characterization and quality control of monoclonal...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), provides $417,400.00 to develop and advance mass spectrometry imaging (MSI) tools for comprehensive chemical characterization of the glycome (the complete repertoire of cell carbohydrates) at tissue and cellular resolutions. The research aims to overcome current limitations in glycome imaging by utilizing various ionization and...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,539,200 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the West Virginia University Research Corporation. The grant, with a project period from July 1, 2024 to April 30, 2028, will fund the development of an integrated system for characterizing the conformational flexibility, heterogeneity, and dynamics of functional oligonucleotides. The project aims to create a novel technology...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA Program 93.859, Biomedical Research and Research Training, provides $304,196 to Laser Bioanalytics LLC to develop a prototype instrument and techniques for photochemical patterning of lipids in tissue sections. The goal is to enable the use of matrix-assisted laser desorption ionization (MALDI) mass spectrometry to more precisely identify and localize lipid structures, including the location of...
The National Institute of General Medical Sciences (NIGMS) awarded a $306,860 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Mixedlcmedia LLC, a small disadvantaged business located in West Newton, MA. The grant, awarded on September 16, 2024 with a completion date of August 31, 2025, will fund the development and evaluation of a commercialization-ready prototype ultra-low flow liquid chromatography (ULF LC) platform. This specialized technology, based...