This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), supports the development of novel ion chemistry and instrumentation for the characterization of proteins, nucleic acids, and heterogeneous bio-complexes using tandem mass spectrometry. The $1,463,792 award, effective from May 1, 2024 to April 30, 2029, will fund efforts to extend the utility of mass spectrometry and tandem mass...
The National Institute of General Medical Sciences (NIGMS) awarded a $390,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Georgia State University Research Foundation Inc. The grant, effective from February 1, 2025 to January 31, 2030, will support the development of a versatile, small molecule-based platform to map the "reader proteins" that interact with carbohydrates (glycans) on proteins and lipids. This research aims to decipher...
This $390,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support a research program at Georgetown University focused on developing multiparametric fluorescence microscopy techniques. The goal is to create an integrated imaging workflow that can simultaneously measure and correlate various cellular properties such as metabolism, protein diffusion, and membrane fluidity across multiple...
The National Institute of General Medical Sciences (NIGMS) awarded a $271,495 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Zeteo Tech, Inc. for the development and evaluation of a time-of-flight (TOF) mass spectrometer system with matrix-assisted laser desorption/ionization (MALDI) for fast analysis of antibodies and related macromolecular immune complexes. The project aims to utilize a novel high-temperature superconducting nanowire detector to...
The National Institute of General Medical Sciences (NIGMS) awarded Massmatrix Inc. a $316,825 Project Grant under the Biomedical Research and Research Training Program (CFDA 93.859) to advance native mass spectrometry (MS) analysis. The project aims to develop an innovative intact mass deconvolution method that will improve the speed, accuracy, and user-friendliness of protein and nucleic acid molecular weight determination using MS. Key objectives include implementing enhanced deconvolution...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,469,739 Project Grant (CFDA 93.859 Biomedical Research and Research Training) to the Research Foundation of the City University of New York (RFCUNY) to purchase a TIMSTOF-FLEX MALDI-2 high-resolution mass spectrometer. This novel instrument will support biomedical research projects in twelve laboratories across CUNY and nearby institutions, including investigations into the conformational dynamics of light-sensitive proteins...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA Program 93.859, Biomedical Research and Research Training, provides $304,196 to Laser Bioanalytics LLC to develop a prototype instrument and techniques for photochemical patterning of lipids in tissue sections. The goal is to enable the use of matrix-assisted laser desorption ionization (MALDI) mass spectrometry to more precisely identify and localize lipid structures, including the location of...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $375,000 in funding to Rowan University from September 15, 2024 to June 30, 2029. The project focuses on developing a sensor-like liquid chromatography-mass spectrometry (LC-MS) platform for rapid, real-time monitoring of targeted small molecule metabolites in complex biological systems. Key objectives include achieving...
This Project Grant award of $306,710 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will enable Z Biotech, LLC to develop a novel glycan-based analysis system. The goal is to create an automated software solution for rapid and affordable glycan structural analysis, which is critical for understanding cell function, disease processes, and therapeutic protein stability. Key objectives include: 1) Enhancing the...
This Project Grant award from the National Cancer Institute under the Cancer Biology Research (CFDA 93.396) program provides $465,028 to North Carolina State University to advance functional mass spectrometry imaging (FMSI) methodology. The research aims to improve the sensitivity and extend the observable metabolic window of FMSI techniques, demonstrate FMSI's ability to detect tissue oxygenation and perfusion dynamics, and measure pentose phosphate pathway activity in tissues. The project will...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), provides $417,400.00 to develop and advance mass spectrometry imaging (MSI) tools for comprehensive chemical characterization of the glycome (the complete repertoire of cell carbohydrates) at tissue and cellular resolutions. The research aims to overcome current limitations in glycome imaging by utilizing various ionization and post-ionization sources, orthogonal analyses, on-tissue chemical derivatization, in-tissue digestion, and glycan enrichment strategies. The award is held by the Pacific Northwest National Laboratory division of Battelle Memorial Institute, a federally-funded research and development center, and the project will run from April 10, 2025 to March 31, 2030. Successful completion of this research is expected to create a robust, high-throughput capability for glycome imaging, enabling a better understanding of how glycome processing and redistribution mediate physiological and pathological processes at the cell-specific level.