Project Grant R34EY038248
- Federal Grant Award Summary The National Eye Institute (NEI) awarded Boston Children's Hospital a Project Grant totaling $132,837 under the Vision Research program (CFDA 93.867) effective May 1, 2026 through April 30, 2028. This award supports research investigating SARM1 (Sterile Alpha and TIR Motif-containing protein 1) as a therapeutic target for two hereditary optic neuropathies: Autosomal Dominant Optic Atrophy (ADOA) and Leber Hereditary Optic Neuropathy (LHON). The research leverages a...
- Federal Grant Award Summary Boston Children's Hospital received a $136,512 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) effective July 1, 2025, through June 30, 2027. The award supports research investigating how intrinsically photosensitive retinal ganglion cells (ipRGCs) transform light information in melanopsin pathways to regulate physiological and behavioral responses. The research employs advanced imaging techniques to measure...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded a $423,866 project grant on May 1, 2026, under the Vision Research program (CFDA 93.867) to The Schepens Eye Research Institute, Inc. in Boston, Massachusetts. This two-year award (concluding April 30, 2028) funds the development of mini-USH2A gene therapy to treat Usher Syndrome Type 2A (USH2), the most common inherited condition causing combined hearing and vision loss. The research addresses a critical technical...
- Federal Grant Award Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded a $545,948 Project Grant to The Schepens Eye Research Institute, Inc., effective April 1, 2026, through March 31, 2030. The award funds research to advance understanding of reactive astrocytes in glaucoma pathogenesis, a leading cause of irreversible blindness worldwide. The research moves beyond traditional neurocentric approaches to examine non-neuronal cellular responses in...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded Massachusetts Eye and Ear Infirmary a Project Grant of $663,406 (Award Date: April 1, 2026; Completion Date: March 31, 2031) under the Vision Research program (CFDA 93.867) to develop novel therapeutic interventions for retinitis pigmentosa (RP). The project will deliver research products including the development of an adeno-associated virus (AAV)-based retinoic acid signaling activator and empirical findings from...
- Federal Grant Award Summary Children's Hospital Medical Center of Akron received a $786,350 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective September 1, 2025, through August 31, 2027. The award funds the implementation and expansion of instrument-based vision screening in primary care pediatric offices serving children ages 3–5 years within the Akron Children's Hospital system. This initiative addresses the critical gap in early...
- Federal Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded The Ohio State University $413,478 on September 22, 2025, to support research on an insulin-accelerated surgical approach to pre-retinal gene therapy for inherited retinal disease (IRD). The grant extends through August 31, 2030, and will deliver research findings and preclinical development of an adeno-associated virus (AAV) delivery methodology designed to improve gene therapy...
- Federal Project Grant Award Summary Ann & Robert H Lurie Children's Hospital of Chicago received a $200,002 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective April 1, 2026 through March 31, 2031. This K23 Career Development Award supports Dr. Jennifer Rossen, a pediatric ophthalmologist, in establishing an independent research program focused on improving clinical outcomes for patients with inherited pediatric cataracts. The...
- Federal Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded a $610,000 Project Grant to The Aird effective September 1, 2025, through August 31, 2026. This award funds the development and commercialization of an Adaptive Optics Optical Coherence Tomography (AO-OCT) system designed for high-resolution, wide-field retinal imaging in rodent models, particularly mice. The primary deliverable is a portable AO-OCT imaging system featuring a...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded $173,016 to the Whitehead Institute for Biomedical Research under the Vision Research program (CFDA 93.867) for a project grant effective August 1, 2025, through July 31, 2027. This award supports systematic identification and mechanistic characterization of novel oxidative protective genes to prevent retinal pigment epithelium (RPE) degeneration in age-related macular degeneration (AMD). The research involves...
The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded a $534,000 Project Grant to Boston Children's Hospital for a two-year planning initiative (April 1, 2026 – March 31, 2028) focused on developing a treatment pathway for pediatric inherited retinal disorders (IRDs) amenable to antisense oligonucleotide (ASO) therapy. The project delivers three primary products: (1) streamlined genetic eligibility analysis protocols to identify cryptic splicing defects in a database of over 3,000 well-characterized pediatric IRD cases; (2) clinical eligibility assessment procedures emphasizing identification of rescuable photoreceptors across diverse retinal diseases and patient presentations; and (3) a comprehensive regulatory template and manual of procedures designed to support future N-of-1 clinical trials of ASO treatment for pediatric IRDs. The award supports a multidisciplinary team with complementary expertise in ASO drug development, pediatric retinal diseases, and low vision care. The anticipated outcomes address a critical clinical need by clarifying patient selection criteria and establishing feasible pathways to early, effective ASO treatment for pediatric patients with IRDs. The deliverables emphasize a patient-centric approach that integrates scientific, medical, feasibility, and ethical criteria to advance precision treatment options for children currently facing lifetime blindness. This planning grant establishes foundational infrastructure and procedures intended to facilitate subsequent clinical development and regulatory approval of ASO therapies for this pediatric population.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $534.0k | 4/28/26 |