Project Grant K08EY036957
- This Project Grant award from the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) is funding research to develop an innovative gene therapy approach using self-amplifying and self-splicing RNA technologies. The $346,500 award, spanning September 2024 to September 2026, aims to evaluate the longevity, immunogenicity, and potential in vivo side effects of this novel mRNA-based therapy for treating inherited retinal dystrophies. The award recipient, The...
- The federal Project Grant award of $427,625 was provided by the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867). The award aims to investigate the interplay between debris/dying cell clearance by specific phagocytes in the retina and the possibility of improving retinal tissue healing in oxygen-induced retinopathy (OIR). The research will use chimeric efferocytosis (CHEF) receptors to improve the efferocytic capacity of retinal phagocytes and evaluate the impact on...
- This federal Project Grant award of $248,999.00 from the National Eye Institute (NEI), under the Vision Research grant program (CFDA 93.867), supports research to understand how neuronal activity influences retinal angiogenesis and blood-retina barrier (BRB) maturation. The primary awardee, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, is conducting investigations to elucidate the role of neurotransmitters, particularly glutamate, in regulating these...
- This $249,000 federal Project Grant awarded by the National Eye Institute (CFDA 93.867 - Vision Research) to Indiana University aims to elucidate the fundamental mechanisms that enable the retina to establish functional connections following gene therapy. The research objectives are to determine the recovery of spatial and temporal processing in on and off retinal pathways, and to evaluate the contribution of synaptic remodeling and neurotransmitter release homeostasis to the structure and...
- This federal Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) provides $144,362 to support research on the role of hyperglycemia and hyperinsulinemia in the breakdown of the blood-retinal barrier in diabetic retinopathy. The project aims to identify the spatial localization and functions of claudins, key tight junction proteins, in the retinal pigment epithelium (RPE) and test the hypothesis that regulation of RPE claudins by hyperglycemic...
- This Project Grant award from the National Eye Institute (NEI), part of the U.S. Department of Health and Human Services, is funding Bedrock Therapeutics, Inc. to develop a novel gene therapy treatment for neovascular age-related macular degeneration (nAMD), a leading cause of blindness in people over 50. The $310,952 award supports Bedrock's research to combine an adeno-associated virus (AAV) vector delivery system with a therapeutic protein (SCIM) to reduce inflammation and vascular changes in...
- This federal Project Grant award of $156,354 from the National Eye Institute's (NEI) Vision Research program (CFDA 93.867) supports research to advance the treatment and understanding of oculocutaneous albinism type 1 (OCA1) through gene therapy. The research aims to: 1) identify the optimal therapeutic window and delivery route for adeno-associated viral vector (AAV)-based TYR gene therapy; 2) administer AAV-TYR vectors at critical time points in retinal development to rescue ipsilateral...
- The National Eye Institute (NEI), under the federal Vision Research grant program (CFDA 93.867), awarded a $306,814 Project Grant to Piximune, Inc. of Durham, North Carolina. The grant supports the development of an "antibody-based gene-agnostic treatment for inherited retinal degeneration," which aims to address the significant debris burden and secondary damage caused by the death of rod photoreceptor cells in patients with retinitis pigmentosa (RP). The proposed mechanism of...
- This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $513,371.00 in funding to The Ohio State University to conduct a multifaceted investigation into the mechanisms by which oxidative stress leads to the activation of the cGAS-STING pathway in the retina and retinal pigment epithelium (RPE). The 5-year project aims to: 1) Investigate the molecular mechanisms governing the escape of self-DNA into the cytosolic compartment during oxidative retinal...
- This federal Project Grant award of $595,302 from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) supports research to understand how glucose and lactate support photoreceptor health and function. The research aims to determine whether the retinal pigment epithelium (RPE) utilizes glucose for its own functions or spares it for the neural retina, and whether glucose transport across the outer blood-retinal barrier is essential for maintaining photoreceptor...
The Project Grant award titled "INSULIN-ACCELERATED SURGICAL APPROACH TO PRE-RETINAL GENE THERAPY" was provided by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867). The $206,739 award to The Ohio State University, effective September 22, 2025, supports research to develop a novel adeno-associated virus (AAV) administration approach that combines a pre-retinal delivery method with adjuvant insulin administration. This aims to accelerate the uptake of AAV into retinal cells as an alternative to the current subretinal delivery method for inherited retinal disease (IRD) gene therapy treatments. The project seeks to address the challenges of ongoing retinal/retinal pigment epithelium atrophy and potential immune responses observed with existing subretinal AAV delivery approaches.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $206.7k | 9/22/25 |