Project Grant R21NS151075
- The National Institute of Neurological Disorders and Stroke awarded Boston Children's Hospital $705,715 on February 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct a multiomics investigation of sudden unexplained pediatric deaths. The research builds on Boston Children's Hospital's prior work in sudden unexpected death in pediatrics (SUDP) by integrating phenotypic and genetic data from the NIH/CDC Sudden Death in...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services, awarded Boston Children's Hospital $577,573 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds functional validation of candidate genes implicated in refractory focal epilepsy, with emphasis on mosaic variants in mTOR pathway genes and non-mTOR genes such as SLC35A2. Boston Children's...
- Federal Grant Award Summary Boston Children's Hospital received a $267,000 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2025, with completion anticipated by July 31, 2027. The award funds research to identify shared molecular mechanisms underlying congenital heart disease (CHD) and neurodevelopmental delay and disability (NDD) by characterizing dysregulated gene expression in...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $580,605 to The Children's Hospital Corporation, doing business as Boston Children's Hospital, on August 7, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research investigating the organization, plasticity, and regenerative capacity of reticulospinal neurons...
- Federal Grant Award Summary Boston Children's Hospital received a $279,644 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 1, 2025, with completion scheduled for August 31, 2027. The grant funds research to develop and validate time to return of spontaneous circulation (ROSC) as a novel primary outcome measure for pediatric in-hospital cardiac arrest (P-IHCA) clinical trials. The research...
- The National Institute of Child Health and Human Development awarded Boston Children's Hospital $356,000 on September 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) to develop artificial intelligence models that predict neurocognitive outcomes in children with congenital heart disease by integrating clinical, surgical, genomic, and neuroimaging data. The research addresses the gap that nearly half of children and adolescents with...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded Boston Children's Hospital $674,950 on January 16, 2026, to dissect neural circuits that mediate top-down control of sympathetic nervous system functions under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). Boston Children's Hospital will conduct basic neuroscience research analyzing...
- The National Institute of Child Health and Human Development awarded Massachusetts General Hospital $499,918 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the genetic etiologies of stillbirth as an extreme manifestation within the developmental disorders continuum. The recipient will aggregate genomic and phenotypic data from an initial sequencing cohort of more than 1,000 stillbirth cases and their family members,...
- The National Institute of Child Health and Human Development awarded The Children's Hospital Corporation (doing business as Boston Children's Hospital) $431,781 on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the impacts of genetic testing in individuals with cerebral palsy. The project will examine family perspectives on the psychosocial impact and utility of genetic testing for cerebral palsy, assess whether a genetic...
- The National Heart, Lung, and Blood Institute awarded The Children's Hospital Corporation, doing business as Boston Children's Hospital, $857,878 for a Project Grant (R01HL188153) on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837). The award funds development and evaluation of pediatric cardiac foundation models—machine learning models pre-trained on large volumes of unlabeled electrocardiogram (ECG), echocardiogram (ECHO), chest X-ray, and clinical text...
The National Institute of Neurological Disorders and Stroke awarded Boston Children's Hospital $489,500 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to evaluate candidate genes for sudden unexpected death in pediatrics using zebrafish mutant larvae models. The research addresses the gap between genetic abnormalities identified in sudden unexpected infant death and sudden unexpected death in childhood cases and clinically relevant mechanistic models. The recipient will evaluate genes identified through sudden unexpected death cohort sequencing studies for survival outcomes in zebrafish mutant larvae. For genes showing decreased survival in the models, the team will conduct detailed studies examining evidence of brain developmental abnormalities and seizures. The long-term objectives are to understand the mechanisms underlying premature sudden death in infants and children and develop preventive intervention strategies. Boston Children's Hospital, a Harvard Medical School affiliate and nonprofit pediatric teaching hospital, performs the work at its facility in Boston, Massachusetts. The period of performance runs from August 15, 2026, through July 31, 2028. This is a Project Grant assistance type.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $489.5k | 8/12/26 |