Project Grant R56NS150428
- The National Institute of Neurological Disorders and Stroke awarded Boston Children's Hospital $489,500 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to evaluate candidate genes for sudden unexpected death in pediatrics using zebrafish mutant larvae models. The research addresses the gap between genetic abnormalities identified in sudden unexpected infant death and sudden unexpected death in childhood cases and...
- The National Institute of Neurological Disorders and Stroke awarded Cincinnati Children's Hospital Medical Center $1.614 million on September 11, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct basic research on epileptogenesis mechanisms in mtoropathies and develop AAV-mediated gene therapy approaches for intractable epilepsy caused by mTOR pathway mutations. The research leverages newly developed mouse models of...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $580,605 to The Children's Hospital Corporation, doing business as Boston Children's Hospital, on August 7, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research investigating the organization, plasticity, and regenerative capacity of reticulospinal neurons...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded The General Hospital Corporation (Massachusetts General Hospital) $234,070 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds a five-year mentored patient-oriented research career development program (K23 mechanism) investigating how direct electrical...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded Boston Children's Hospital $674,950 on January 16, 2026, to dissect neural circuits that mediate top-down control of sympathetic nervous system functions under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). Boston Children's Hospital will conduct basic neuroscience research analyzing...
- The National Institute of Neurological Disorders and Stroke awarded Boston Children's Hospital $489,500 on March 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate cerebrospinal fluid neurotransmitter-based regulation of the choroid plexus blood-brain barrier. The research examines how excessive cerebrospinal fluid glutamate impairs choroid plexus barrier integrity through the metabotropic glutamate receptor 8...
- The National Institute of Neurological Disorders and Stroke awarded Seattle Children's Hospital $516,175 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the role of MN1 in central nervous system developmental malformations. The research compares MN1 null and C-terminal truncation mutant mice to characterize cerebellar and cerebral cortex phenotypes associated with MN1 C-terminal truncation syndrome,...
- The National Institute of Neurological Disorders and Stroke awarded the Epilepsy Foundation of America $491,786 on September 15, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to plan epilepsy health disparities research through community co-production. The recipient will develop methods to engage local community partners and epilepsy patient and family partners in co-producing research priorities for epilepsy health disparities...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded Boston Children's Hospital a $489,500 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) for the period July 1, 2025 through June 30, 2027. This R21 exploratory research grant supports a collaborative investigation into stimulus-responsive microproteins in human microglia-like cells, focusing on mRNA translational...
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the Department of Health and Human Services National Institutes of Health, awarded $153,560 to the Broad Institute, Inc. (doing business as Broad Institute of MIT and Harvard) on December 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research examining how excitatory neurons regulate interneuron fate, position, and survival during...
The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services, awarded Boston Children's Hospital $577,573 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds functional validation of candidate genes implicated in refractory focal epilepsy, with emphasis on mosaic variants in mTOR pathway genes and non-mTOR genes such as SLC35A2. Boston Children's Hospital will use zebrafish as an experimental model system to introduce disease-associated single nucleotide variants and create both gain-of-function and loss-of-function mosaic models in AKT1, PIK3CA, PIK3R2, mTOR, PTEN, and SLC35A2. The research team will evaluate brain size, gross structural abnormalities, and neuronal morphology through immunohistochemistry to assess how the degree of abnormality correlates with mosaic variant burden and epilepsy phenotypes in humans. The award covers the period of performance from September 1, 2026, through August 31, 2027, with place of performance in Boston, Massachusetts. The Extramural Research Programs in the Neurosciences and Neurological Disorders program supports extramural research including basic research exploring fundamental brain and nervous system structure and function, consistent with NINDS's mission to reduce the burden of neurological disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $577.6k | 8/28/26 |