Project Grant R21HL181712
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $180,174 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Children's Hospital of Philadelphia Research Institute. The grant will fund a study to develop a framework for designing the next generation of pediatric acute respiratory distress syndrome (ARDS) clinical trials. Key objectives include: 1) Comparing heterogeneity of treatment effect (HTE) analysis methodologies in a trial of pediatric...
- The federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), will provide $865,286 to The Children's Hospital Corporation (doing business as Boston Children's Hospital) to develop a high-resolution spatiotemporal lineage map of cardiac development. The research aims to spatiotemporally map early cardiac progenitor lineages and their clonal relationships, map the phylogeny of major myocardial cell...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), will provide $267,000.00 to The Children's Hospital Corporation (doing business as Boston Children's Hospital) for a project titled "Multimodal Characterization of Cardiac-Neurodevelopmental Genes." The project aims to (1) identify mechanisms by which certain genetic syndromes lead to alterations in both heart and brain development,...
- The National Heart, Lung, and Blood Institute (NHLBI), through the Cardiovascular Diseases Research grant program (CFDA 93.837), awarded $793,956 to Resuscitation Innovations LLC, doing business as Advancedcpr Solutions LLC, for the project "HEAD UP CPR AND AORTIC OCCLUSION TO IMPROVE SURVIVAL AFTER REFRACTORY CARDIAC ARREST". This project grant, awarded on January 1, 2025 with a planned completion date of January 23, 2026, aims to develop and evaluate new treatments to improve...
- This $2,024,340 Project Grant was awarded on August 15, 2025 by the National Heart Lung and Blood Institute (NHLBI), part of the National Institutes of Health, under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The grant supports a multi-year research effort at Boston Children's Hospital to optimize outcomes for hematopoietic stem cell transplantation (HCT), an essential treatment for high-risk non-malignant and malignant hematologic diseases. The research project...
- This federal Project Grant award of $889,188.00 from the National Heart Lung and Blood Institute, under the Cardiovascular Diseases Research program (CFDA 93.837), supports the development of a new oxygen therapy called Intravenous Oxygen (IVO2) for treating cardiac arrest. The project aims to optimize the molecular structure of polymeric microbubbles that can safely deliver high volumes of oxygen intravenously, without risks of embolism or vascular obstruction. This innovative approach is...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $816,119 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Oregon Health & Science University (OHSU). The overall objective of this 4-year project is to conduct an in-depth analysis of pediatric prehospital emergency ventilation and identify the ventilation strategy associated with the best patient outcomes. The project will leverage data collected through the NHLBI-funded PEDI-PART trial, which...
- The National Heart Lung and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), awarded a $536,142 Project Grant to Saint Luke's Hospital of Kansas City to conduct the "Improving Quality in Cardiac Arrest via Resuscitation Academy Training: The IQ-CART Study". The grant aims to evaluate whether participation in the Resuscitation Academy training program is associated with improved survival rates for out-of-hospital cardiac arrest (OHCA) cases. The...
- This $2,394,542 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will fund a randomized controlled trial to test the effect of transferring patients resuscitated from out-of-hospital cardiac arrest to a specialty cardiac care center versus usual care. The study aims to: 1) estimate the impact of specialty cardiac care on functional recovery, 2) identify the minimum clinical and operational standards for specialty cardiac arrest...
- This Project Grant award for $879,567.00, funded by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports research on lung injury in pediatric hematopoietic cell transplant (HCT) recipients. The research team at The Children's Hospital of Philadelphia (CHOP) will conduct a comprehensive characterization of the clinical, proteomic, and cell-free DNA biomarker profiles associated with the development of lung injury after HCT in...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $279,644 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Children's Hospital Corporation (doing business as Boston Children's Hospital) to study "Time to ROSC as a Novel Outcome for Pediatric Cardiac Arrest Trials." The project aims to develop new trial design techniques to enhance the feasibility of conducting high-quality randomized controlled trials for interventions to improve outcomes in pediatric in-hospital cardiac arrest, which is a devastating condition with high mortality and morbidity. The grant will fund research to explore using "time to return of spontaneous circulation" as an alternative primary outcome measure, as traditional binary endpoints like survival to discharge have significant limitations in this field. The award period is from Sep 1, 2025 to Aug 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $279.6k | 8/28/25 |