Project Grant R03HD123801
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded The Children's Hospital Corporation, doing business as Boston Children's Hospital, $177,927 under the Trans-NIH Research Support program (CFDA 93.310) on September 1, 2026, to develop and maintain a software package of deep neural networks for robust brain age estimation and to provide ongoing technical support for five NIH-funded research projects. The award funds development of artificial...
- The National Heart, Lung, and Blood Institute awarded The Children's Hospital Corporation, doing business as Boston Children's Hospital, $857,878 for a Project Grant (R01HL188153) on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837). The award funds development and evaluation of pediatric cardiac foundation models—machine learning models pre-trained on large volumes of unlabeled electrocardiogram (ECG), echocardiogram (ECHO), chest X-ray, and clinical text...
- The National Institute of Child Health and Human Development awarded The Children's Hospital Corporation $775,598 on September 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) to develop machine-learning algorithms that automatically detect classic metaphyseal lesions—fractures highly specific to inflicted infant trauma—in skeletal survey radiographs. The recipient, doing business as Boston Children's Hospital, will train algorithms on both...
- Federal Grant Award Summary Boston Children's Hospital received a $267,000 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2025, with completion anticipated by July 31, 2027. The award funds research to identify shared molecular mechanisms underlying congenital heart disease (CHD) and neurodevelopmental delay and disability (NDD) by characterizing dysregulated gene expression in...
- The National Institute of Biomedical Imaging and Bioengineering awarded The Children's Hospital Corporation (Boston Children's Hospital) $267,000 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop and expand the Fetal and Neonatal Development Imaging (FEDI) open-source software platform for analyzing early brain development via magnetic resonance imaging. The project addresses a critical gap in...
- The National Institute of Child Health and Human Development awarded Massachusetts General Hospital $681,793 on June 23, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to map the neuroarchitecture and connectivity development of the human cerebellum during the first postnatal year using cross-scale imaging techniques. The research addresses the gap between in vivo and ex vivo imaging of perinatal cerebellar injury, which occurs in up to 19% of...
- The National Institute of Neurological Disorders and Stroke awarded Boston Children's Hospital $489,500 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to evaluate candidate genes for sudden unexpected death in pediatrics using zebrafish mutant larvae models. The research addresses the gap between genetic abnormalities identified in sudden unexpected infant death and sudden unexpected death in childhood cases and...
- The National Heart, Lung, and Blood Institute awarded Children's Research Institute $1,818,088 on July 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate how postnatal hypoxemia—reduced blood oxygen levels present in cyanotic congenital heart disease—impacts cardiac maturation and surgical recovery outcomes in pediatric patients. The project will examine the interaction between hypoxemia, myocardial immaturity, and postoperative complications through...
- The National Institute of Child Health and Human Development awarded The Children's Hospital Corporation (doing business as Boston Children's Hospital) $431,781 on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the impacts of genetic testing in individuals with cerebral palsy. The project will examine family perspectives on the psychosocial impact and utility of genetic testing for cerebral palsy, assess whether a genetic...
- The National Institute of Child Health and Human Development awarded the Research Institute At Nationwide Children's Hospital $726,423 on July 1, 2026, for a project grant (R01HD120364) to develop MINDGUARD, a multimodal artificial intelligence system for early prediction of post-concussion mental health sequelae in youth aged 11 to 17. The project develops and deploys an AI-based data collection system (MINDGUARD) that integrates structured electronic health records from approximately 20,000...
The National Institute of Child Health and Human Development awarded Boston Children's Hospital $356,000 on September 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) to develop artificial intelligence models that predict neurocognitive outcomes in children with congenital heart disease by integrating clinical, surgical, genomic, and neuroimaging data. The research addresses the gap that nearly half of children and adolescents with congenital heart disease experience neurocognitive challenges including reduced full-scale IQ and executive function, yet existing approaches relying on neuroimaging or genetic studies alone have not fully explained why outcomes vary so widely among individuals. The award funds two specific aims: evaluating the relevance of common genetic architectures of brain traits from the general population to congenital heart disease, and developing artificial intelligence models that predict full-scale IQ and executive function by integrating the four data modalities. The work builds on a preliminary model developed using detailed clinical, genetic, and brain MRI data from 89 participants with congenital heart disease. Performance occurs in Boston, Massachusetts, with a period of performance extending through August 31, 2028. The recipient organization, Boston Children's Hospital, is a nonprofit pediatric teaching hospital and Harvard Medical School affiliate that operates as a federal research institution, conducting the research through on-site laboratories and clinical facilities.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $356.0k | 8/20/26 |