This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $802,762 to The University of Texas Southwestern Medical Center to investigate the genetic mechanisms underlying congenital heart disease (CHD). The key objectives are to: 1) Define the transcription factors and gene regulatory networks controlling human cardiac development; 2) Identify and characterize genetic variants regulating cardiac gene programs; and 3)...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $844,386 to support research on the genetic landscape of childhood interstitial and diffuse lung diseases (CHILD). The key objectives are to: 1) Define molecular profiles of 300 CHILD lung biopsy samples to identify patient clusters with similar underlying causes, 2) Analyze whole exome sequence data from 400 children with...
This Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) will provide $315,999 to the Research Institute at Nationwide Children's Hospital to conduct research aimed at uncovering the role of incomplete penetrance genes in congenital heart disease (CHD). The key products and services to be delivered include: Sourcing a large cohort of CHD families from multiple data sources to perform a genetic association study and pedigree...
This $506,984 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), aims to investigate the role of the LRP1 gene in the development of congenital heart disease (CHD). The primary objectives are to: Examine the deployment and migration of cardiac neural crest cells (CNCCs) and their dependence on LRP1 using in vitro and in vivo cell lineage fate mapping analysis. Investigate the cellular and molecular...
This $161,500 Project Grant was awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant is intended to establish basic science-clinical collaborations to understand the molecular mechanisms of heterotaxy, a severe form of congenital heart disease that affects 3-4% of patients with congenital heart defects. The funding will support research at the University of Virginia to...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under CFDA 93.837 "Cardiovascular Diseases Research" will provide $126,059 from September 1, 2024 to August 31, 2029 to the University of Colorado-Denver. The project aims to use proteomics and metabolomics approaches to study the systems biology of acute and chronic multi-organ failure in children with congenital heart disease (CHD). Specifically, the project will measure changes in the circulating...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $487,567 to Indiana University to conduct integrative genomic analysis and develop high-dimensional risk prediction models for congenital heart defects (CHDs). The research aims to identify genetic variants and biological pathways associated with CHDs, as well as build predictive models leveraging genetic, epigenetic,...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $167,940 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to The Children's Hospital Corporation (doing business as Boston Children's Hospital) with a project period from Sep 20, 2024 to Aug 31, 2029. The grant aims to develop a novel mouse model of flow-induced pulmonary hypertension (PH) that better represents the physiological conditions observed in patients with congenital heart disease. Additionally, the project...
This $701,842 Project Grant, awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), will support research at the University of South Florida to investigate the role of the CDK13 gene in the development of congenital heart defects. The project aims to utilize mouse models and human induced pluripotent stem cell-derived cardiomyocytes to better understand how mutations in CDK13 disrupt RNA processing and lead to cardiac...
This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $127,305 to The Children's Hospital Corporation (doing business as Boston Children's Hospital) to conduct research on "Unraveling Immune Cell Interactions and Multicellular Dynamics in GNAQ-Driven Capillary Malformation". The research aims to determine the role of macrophages in capillary malformations caused by a specific GNAQ gene mutation, as well as...