Project Grant R21NS140780
- This $233,250 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will fund research at The Washington University to investigate the potential of hyperpolarized 13C magnetic resonance spectroscopic imaging (HP 13C MRSI) and ultra-short echo time magnetization transfer (UTE-MT) imaging to non-invasively study the role of lactate metabolism and...
- This Project Grant award in the amount of $521,839.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The grant supports research at the University of California, San Diego to investigate the molecular mechanisms underlying the activation of microglia, which contribute to oxidative stress and tissue damage in multiple sclerosis (MS)....
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $104,433 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Washington University in St. Louis to conduct research on examining microglia reactivation in multiple sclerosis (MS). The project aims to define the gene signature of disease-associated microglia (DAM) and understand how the function of these cells is affected by repeated activation, as...
- This $439,027 Project Grant was awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The grant aims to demonstrate the ability of the gut microbiome-derived metabolite indole lactate (ILA) to overcome barriers to myelin repair in multiple sclerosis (MS) and identify the mechanism by which ILA promotes remyelination. The research will be conducted...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will fund the development of an in vitro platform to investigate the role of matrix metalloproteinase-9 (MMP-9) in blood-brain barrier permeability and neurovascular unit dysfunction in multiple sclerosis (MS). The $534,964 award to Michigan State University aims to enhance understanding of...
- This $614,009 federal Project Grant award was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research into the molecular mechanisms of oligodendrocyte myelination and remyelination, which are critical processes for addressing demyelinating diseases of the central nervous system like multiple sclerosis. The awardee, Children's Hospital...
- This $198,928 Project Grant was awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The grant will support research at the University of California, San Francisco to elucidate the cellular mechanisms underlying central nervous system injury and progression in multiple sclerosis. Key objectives include determining the role of astrocyte response,...
- This federal Project Grant award of $458,189 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research focused on understanding how specific membrane-remodeling factors regulate oligodendrocyte membrane dynamics and myelination in the central nervous system. The research aims to elucidate the mechanisms by which these factors shape...
- This Project Grant award, totaling $547,846 and provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to optimize and characterize small molecule GPR17 antagonists for potential treatment of multiple sclerosis (MS). The research will focus on understanding the role of the GPR17 receptor in oligodendrocyte maturation and remyelination, with the goal of...
- This $374,749 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research at Boise State University to investigate the role of FOXO1, NMMLCK, and HDAC6 in blood-brain barrier dysfunction and disease progression in multiple sclerosis. The research aims to identify mechanisms governing blood-brain barrier function and evaluate their therapeutic...
This federal Project Grant award of $427,104.00, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is focused on identifying biomarkers of demyelination and remyelination in a mouse model of multiple sclerosis (MS). The key objectives are to profile proteins and lipids in tissue-derived and plasma-derived extracellular vesicles to discover novel biomarkers that could facilitate the development of new therapeutic strategies for promoting repair and remyelination in MS. The award period runs from September 23, 2025 to August 31, 2027, and is being provided to The Johns Hopkins University, a leading academic research institution.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $427.1k | 9/23/25 |