This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $614,009 to support research focused on understanding the molecular mechanisms involved in oligodendrocyte myelination and remyelination. The goal is to identify critical factors that promote myelin production and overcome inhibitory signals, with the aim of improving myelin repair in demyelinating diseases like multiple sclerosis. Key research activities include utilizing spatio-temporally specific mutagenesis approaches to study the role of class I histone deacetylase isoforms in remyelination, as well as investigating the regulatory network involving the HDAC3-ZNHIT1 complex and its impact on myelination and remyelination. The award period runs from June 15, 2025 to April 30, 2030, and the research will be conducted at the Children's Hospital Medical Center in Cincinnati, Ohio.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $614.0k | 6/6/25 |