This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) provides $233,250 to The Washington University's Office of Sponsored Research Services Division to investigate the potential of hyperpolarized 13C magnetic resonance spectroscopic imaging (HP 13C MRSI) and ultra-short echo time magnetization transfer (UTE-MT) imaging in studying lactate metabolism and remyelination processes in multiple sclerosis (MS). The research aims to develop and validate these clinically translatable MRI techniques as non-invasive biomarkers to monitor disease progression and evaluate the efficacy of remyelinating therapies in two MS mouse models. The award period runs from December 2024 to November 2026.
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