This $1,361,648 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support a multi-scale, multi-modal longitudinal imaging study to examine the association of cognitive function with changes in brain structure, function, and neuronal integrity in patients with multiple sclerosis (MS). The primary research objectives are to: 1)...
This federal Project Grant award, totaling $653,192.00 and provided by the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders, supports a longitudinal study on non-invasive imaging of pathological fibrin deposition and its effects on progressive neurodegeneration in the human brain. The study, conducted by the primary awardee The General Hospital Corporation (doing business as...
This Project Grant award of $547,846 from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders will support research to optimize and characterize small molecule GPR17 antagonists for potential treatment of multiple sclerosis (MS). The key objectives are to: 1) synthesize at least 100 novel analogs of the lead compound SN-191 through structural modifications, 2) evaluate the synthesized...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is focused on developing a software platform to automate the analysis of quantitative MRI biomarkers for monitoring and staging multiple sclerosis (MS). The $353,942 award to Microstructure Imaging Inc., with a project period from September 2024 to August 2026, aims to: 1) curate...
This $233,250 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will fund research at The Washington University to investigate the potential of hyperpolarized 13C magnetic resonance spectroscopic imaging (HP 13C MRSI) and ultra-short echo time magnetization transfer (UTE-MT) imaging to non-invasively study the role of lactate metabolism and...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $506,083.00 to Artificial Axon Labs Inc. to develop a novel biomimetic 3D-printed drug discovery platform called "Artificial Axons" for screening remyelinating compounds to treat multiple sclerosis (MS) and other myelin diseases. The key products and services...
This federal Project Grant award of $614,009, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research aimed at understanding the molecular mechanisms of oligodendrocyte myelination and remyelination. The research, conducted by the Children's Hospital Medical Center in Cincinnati, Ohio, focuses on identifying critical factors that promote myelin...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $541,109 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Washington. The 5-year grant, beginning January 1, 2025, will fund research to quantify myelin loss and recovery in ischemic stroke patients using a novel magnetic resonance imaging (MRI) technique called single-point macromolecular proton fraction (MPF) mapping. The...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $431,750.00 to support research aimed at overexpressing the CYP2C11 enzyme in peri-lesion astrocytes of mice with multi-infarct dementia (MID). The goal is to enhance cerebral blood flow and suppress neuroinflammation, potentially improving cognitive function in this prevalent...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) provides $654,287 to the Icahn School of Medicine at Mount Sinai to conduct a study on cognitive impairment in multiple sclerosis (MS). The goal is to develop a psychometrically valid and biologically informed model of cognitive status in relapsing-remitting and progressive MS by...