The University of Texas Medical Branch at Galveston (UTMB) received a $458,189 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to conduct research on how membrane-remodeling factors regulate oligodendrocyte morphology and central nervous system (CNS) myelination. The research aims to:
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Identify membrane-remodeling factors expressed in oligodendrocytes and determine their sufficiency to remodel oligodendrocyte and myelin sheath morphology.
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Assess the necessity of these factors in establishing proper oligodendrocyte complexity and CNS myelination.
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Evaluate the role of these factors in promoting proper remyelination kinetics following demyelination.
The 5-year project beginning on March 1, 2025 seeks to unravel the mechanisms by which intrinsic membrane-remodeling proteins shape oligodendrocyte form and function to support neural circuit development, plasticity, and repair.
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