This $233,250 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will fund research at The Washington University to investigate the potential of hyperpolarized 13C magnetic resonance spectroscopic imaging (HP 13C MRSI) and ultra-short echo time magnetization transfer (UTE-MT) imaging to non-invasively study the role of lactate metabolism and...
This federal Project Grant award of $614,009, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research aimed at understanding the molecular mechanisms of oligodendrocyte myelination and remyelination. The research, conducted by the Children's Hospital Medical Center in Cincinnati, Ohio, focuses on identifying critical factors that promote myelin...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $541,109 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Washington. The 5-year grant, beginning January 1, 2025, will fund research to quantify myelin loss and recovery in ischemic stroke patients using a novel magnetic resonance imaging (MRI) technique called single-point macromolecular proton fraction (MPF) mapping. The...
This Project Grant award of $547,846 from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders will support research to optimize and characterize small molecule GPR17 antagonists for potential treatment of multiple sclerosis (MS). The key objectives are to: 1) synthesize at least 100 novel analogs of the lead compound SN-191 through structural modifications, 2) evaluate the synthesized...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $506,083.00 to Artificial Axon Labs Inc. to develop a novel biomimetic 3D-printed drug discovery platform called "Artificial Axons" for screening remyelinating compounds to treat multiple sclerosis (MS) and other myelin diseases. The key products and services...
This federal Project Grant award, valued at $599,204.00 and provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the cellular mechanisms that drive learning-induced myelin remodeling and its role in motor learning. The key objectives are to: (1) determine whether calcium signaling is required for myelin sheath shortening...
This Project Grant award of $534,964.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will fund the development of an in vitro platform to investigate the role of matrix metalloproteinase-9 (MMP-9) in the breakdown of the blood-brain barrier and extracellular matrix in multiple sclerosis. The research team at Michigan State University will integrate real-time...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $424,234 to The Leland Stanford Junior University to conduct research on using the PET radiotracer [18F]OP-801 to track innate immune activation and therapeutic response in mouse models of multiple sclerosis (MS). The goal is to establish the sensitivity and potential utility of...
This $497,196 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports the development of a novel magnetic resonance spectroscopic imaging (MRSI) pulse sequence at 3 Tesla. The goal is to simultaneously map both downfield and upfield proton metabolic signals in the human brain, which may provide important new insights into brain metabolism....
This $1,361,648 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support a multi-scale, multi-modal longitudinal imaging study to examine the association of cognitive function with changes in brain structure, function, and neuronal integrity in patients with multiple sclerosis (MS). The primary research objectives are to: 1)...