Project Grant R21NS137072
- This federal Project Grant award of $460,563.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) is supporting research focused on developing a therapeutic intervention for Parkinson's disease. The key products or services being delivered include: Investigating the potential of the brain-specific chaperone protein ProSAAS as a therapeutic target for Parkinson's disease....
- This $816,661 Project Grant award, issued on June 1, 2025 by the National Institute on Aging (CFDA 93.866 Aging Research program), supports comprehensive research aimed at elucidating the molecular mechanisms underlying tauopathies such as Alzheimer's disease and frontotemporal dementia. The project, titled "Aberrant Proteomes in Tauopathy: Revealing Functional Consequences via Multimodal Proteomics", combines expertise in mass spectrometry-based proteomics and functional genomics to...
- This $3,109,857 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports the development and validation of a human induced pluripotent stem cell (iPSC)-derived hippocampal assembloid model to study the interaction between interneurons, tau toxicity, and circuit-related neuronal dysfunction associated with genetic forms of dementia. The research...
- This $1,526,066 Project Grant was awarded by the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), to The Leland Stanford Junior University (Stanford University). The award, with a start date of June 1, 2025 and an ultimate completion date of April 30, 2030, will fund research to investigate the shared mechanisms of tau protein toxicity across multiple neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's disease. The...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will provide $2,723,954.00 to the University of Alabama at Birmingham (UAB) from June 1, 2025 to May 31, 2027. The grant supports research focused on understanding the effects of 14-3-3θ protein phosphorylation on vesicular transport and alpha-synuclein aggregation, which are key mechanisms...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is providing $647,116 to the Regents of the University of Michigan to characterize and target a novel pathway promoting Parkinson's disease (PD) and Parkinson's disease dementia (PDD). The funded research aims to investigate how the interaction between the protease tissue...
- This Project Grant award of $119,367, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to characterize the role of the protein tau and its interactions with RNA processing in frontotemporal dementia (FTD). The principal investigator at the University of California, San Francisco (UCSF) aims to (1) investigate how tau, an RNA-binding protein,...
- This Project Grant award of $717,709 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to discover cellular mechanisms underlying the propagation of misfolded tau protein aggregates in human neurons, which are key drivers of cognitive decline in Alzheimer's disease (AD) and frontotemporal dementia (FTD). The research combines advanced proteomic techniques, deep learning analyses, and transcriptomic profiling using newly generated human induced pluripotent stem...
- This $146,922 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to investigate physiological pathways that modulate the regulation of the tau protein, which is associated with neurodegenerative diseases like Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). The research is being conducted by the Johns Hopkins University and aims to better understand how disruptions in the signaling pathway involving the enzyme GDE2 lead to...
- This $3,081,936 federal Project Grant award was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research at the University of California, San Diego (UCSD) to investigate the mechanisms underlying TDP-43 proteinopathies, which are associated with amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Alzheimer's disease,...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is funding the development of a novel diagnostic assay for Parkinsonian tauopathies. The $446,991 award, made on Aug 7, 2025, supports the creation of aptamer-based ELISA assays to detect two tau peptides that can distinguish progressive supranuclear palsy (PSP) from corticobasal degeneration (CBD) - two challenging Parkinsonian disorders that are often misdiagnosed. The ultimate completion date for this research project is Jul 31, 2027. The principal investigator is based at the University of California, Los Angeles (UCLA), which is a prominent federal research partner across biomedical and technical domains.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $447.0k | 8/7/25 |