This $717,709 Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to Weill Medical College of Cornell University aims to discover Alzheimer's disease (AD)-relevant cellular mechanisms underlying the propagation of misfolded tau aggregates in human neurons. The research will utilize advanced proteomic techniques, including affinity purification mass spectrometry and transcriptomics, in combination with newly generated knockin human induced pluripotent stem cell (iPSC) models expressing different tau isoforms. The study has three specific objectives: 1) determine tau interactomes influenced by amyloid-beta and tau seeding in different tau isoforms, 2) investigate the role of the VPS29 protein in tau aggregation and its impact on proteomic and transcriptomic profiles, and 3) explore how the ufmylation pathway regulates tau aggregation and its interactions with the retromer pathway. The findings from this research are expected to provide unprecedented insights into AD-related tau pathology and inform the development of novel therapeutic strategies.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $717.7k | 5/20/25 |