Project Grant RF1NS144660
- This Project Grant award of $460,625 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is supporting research to investigate the roles of the deubiquitylation pathway in TDP-43 pathology associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The research is being conducted by the University of Massachusetts Medical School (UMMS) and...
- This $2,817,215 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is supporting research to elucidate the role of the TRIM10 protein in maintaining the solubility and function of the TDP-43 protein. TDP-43 misfolds and aggregates in progressive neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) and frontotemporal...
- This federal Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, consolidates multiple research projects into a single larger R35 grant to enable comprehensive exploration of biological mechanisms underlying neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Parkinson's disease. The...
- This $3,360,074 federal Project Grant was awarded on September 15, 2025 by the National Institute on Aging (NIA) under the Aging Research grant program (CFDA 93.866). The grant is funding research led by the University of Pennsylvania to develop short RNA therapeutics that can combat TDP-43 proteinopathy, a key pathological feature of several devastating neurodegenerative disorders including Alzheimer's disease, amyotrophic lateral sclerosis, and frontotemporal dementia. The research aims to...
- This federal Project Grant award, valued at $737,720.00 and provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research at Case Western Reserve University to investigate the role of the ATAD3A protein in regulating the cytoplasmic accumulation of the TDP43 protein, which is a hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia...
- This Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the dysfunction of neuroimmune-related processes in animal models of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) associated with TAR DNA-binding protein 43 (TDP-43). The $251,250 award, effective from Apr 1, 2025 to Mar 31,...
- This Project Grant award of $374,349 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports the development and optimization of a new animal model for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The goal is to create a mouse model that accurately recapitulates the human disease spectrum by incorporating an acetylation-mimicking...
- This $461,900 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to study the mechanisms underlying TDP-43 dependent structural deficits in amyotrophic lateral sclerosis (ALS) muscles. The project, conducted by the Pennsylvania State University, aims to investigate how TDP-43, a protein involved in ALS and other neurodegenerative disorders, affects muscle function and structure. The research will utilize non-canonical amino acid...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $460,625 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Massachusetts Medical School (UMASS Medical) to investigate the role of TDP-43 citrullination in amyotrophic lateral sclerosis (ALS) pathogenesis. The project, led by principal investigators Massi and Xu, aims to elucidate how citrullination, a post-translational...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $2,709,695 in funding to The Trustees of the University of Pennsylvania to conduct research on the role of TRIM11 in regulating the proteins TDP-43 and FUS. The research aims to determine how TRIM11 maintains the functional, soluble state of these proteins and if its...
This $3,081,936 federal Project Grant award was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research at the University of California, San Diego (UCSD) to investigate the mechanisms underlying TDP-43 proteinopathies, which are associated with amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Alzheimer's disease, and other neurodegenerative conditions. The researchers are utilizing a multimodal MERFISH approach to measure key proteins like TDP-43 and dipeptide repeat proteins, while simultaneously analyzing the corresponding transcriptomes of individual cells within intact tissue samples. This integrated single-cell spatial transcriptomics analysis aims to elucidate the precise pathogenic mechanisms driving TDP-43 mislocalization and aggregation, which are hallmarks of C9ORF72 repeat expansion-mediated neurodegeneration. The award period runs from September 2025 through June 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.1m | 9/11/25 |