This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $4,276,054 to The Regents of the University of California, San Francisco (UCSF) to conduct research on the selective vulnerability of genes, cells, and neural networks in mouse tauopathy models of Alzheimer's disease (AD). The project aims to develop quantitative mathematical models to test hypotheses regarding the selective vulnerability of certain brain regions and cell types to the...
The National Institute on Aging (NIA) awarded a $773,816 Project Grant (CFDA 93.866 - Aging Research) to the University of California, Irvine to conduct a comprehensive study on the molecular mechanisms underlying aberrant protein accumulation in Alzheimer's disease-related tauopathies. The project aims to generate cell-type-specific atlases of misprocessed RNAs and proteins in mouse models and human brain tissues to identify new pathways and protein interaction networks involved in...
The National Institute on Aging (NIA) awarded a $7,249,563 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the Regents of the University of California, San Francisco (UCSF). This 3-year award, starting on Aug 1, 2023, will support research to characterize the structural properties and variability of tau protein aggregation in different brain cell types and at different disease stages of Alzheimer's and related dementias (ADRD). The project aims to develop new...
This $519,750 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a 2-year research study by the J. David Gladstone Institutes, a non-profit biomedical research organization in San Francisco. The study aims to explore the underlying molecular mechanisms by which reducing levels of the tau protein can prevent or diminish excitation/inhibition imbalance and network hyperexcitability in the brain. This imbalance has been observed in various...
This federal Project Grant award of $1,118,700.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) to New York University School of Medicine will support research to elucidate the role of pathological tau protein in disrupting endosomal microautophagy (EMI), a critical protein degradation pathway affected in Alzheimer's disease. The research aims to determine which components of the EMI pathway are most vulnerable to tau pathology and whether restoring EMI function can...
This $1,592,854 project grant was awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Illinois to investigate the molecular mechanisms underlying tau protein dysfunction in neurodegenerative tauopathies, including Alzheimer's disease and related dementias. The overarching goal is to understand how disease-related changes in tau conformation and post-translational modifications disrupt tau's normal scaffolding functions and lead to dysregulation of key...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $320,000 will fund a study on alternative polyadenylation (APA) regulation in Alzheimer's disease (AD). The research, conducted by the University of Texas Medical Branch at Galveston, aims to comprehensively profile APA transcripts and gene expression in neurons expressing wild-type and mutant tau proteins. Specifically, the study will leverage the Poly(A)-ClickSeq (PAC-Seq)...
This $437,250 Project Grant award from the National Institute on Aging's Aging Research Program (CFDA 93.866) will enable researchers at the University of California, San Diego (UCSD) to develop new imaging tools to study the tau protein and its involvement in neurodegenerative diseases like Alzheimer's. The grant will fund the creation of a peptide-based fluorescent probe that can detect and measure tau in its different forms - soluble, liquid-liquid phase separated, and liquid-solid aggregated...
This $459,076 federal Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) will support research into the early transcriptional and pathological changes in vulnerable brain regions during the prodromal stage of Alzheimer's disease (AD). The project will leverage single-nucleus RNA sequencing and targeted mass spectrometry analysis of postmortem brain samples from individuals with early-stage AD pathology to profile gene expression changes and identify...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research into the role of local protein synthesis in the development of tau pathology and neurodegeneration associated with Alzheimer's disease. The $1,147,300 grant awarded to Wayne State University will fund a 5-year project to investigate how pathogenic forms of the tau protein interfere with dendritic protein synthesis, which may contribute to the early synaptic dysfunction seen in...