This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $663,376 to The Regents of the University of California, San Francisco to explore the molecular mechanisms underlying the heterogeneity of Alzheimer's disease and related dementias. The project aims to identify key genes that mediate the selective vulnerability of brain regions to distinct pathological protein conformers, such as tau and alpha-synuclein, using a novel computational modeling...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $717,709 to Weill Medical College of Cornell University to conduct research on the mechanisms underlying the propagation of tau aggregates in Alzheimer's disease (AD) and frontotemporal dementia (FTD). The research aims to discover AD-relevant cellular machinery involved in the spread of misfolded tau proteins using advanced proteomic and transcriptomic techniques. The work will be carried out...
The National Institute on Aging (NIA) awarded a $7,249,563 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the Regents of the University of California, San Francisco (UCSF). This 3-year award, starting on Aug 1, 2023, will support research to characterize the structural properties and variability of tau protein aggregation in different brain cell types and at different disease stages of Alzheimer's and related dementias (ADRD). The project aims to develop new...
This Project Grant award of $816,661 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a comprehensive research project entitled "Aberrant Proteomes in Tauopathy: Revealing Functional Consequences via Multimodal Proteomics". The research, conducted by The Regents of the University of California, San Francisco, aims to systematically elucidate the molecular and cellular mechanisms by which pathological tau drives neurodegeneration in Alzheimer's disease...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $757,027 to the University of Washington to conduct research on the synergistic relationship between tau and TDP-43 proteins in Alzheimer's disease. The research aims to identify mechanisms that drive the interaction between these two pathological hallmarks of Alzheimer's and how they contribute to cognitive decline and neurodegeneration. Key activities include using C. elegans models to...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $1,592,854 to the University of Illinois to conduct research on tau protein conformation and its role in Alzheimer's disease and related dementias. The key focus areas include: Defining the effects of tau post-translational modifications on tau function and pathology. This will evaluate how modifications like phosphorylation, acetylation, and cross-linking impact the exposure of tau's regulatory...
This $519,750 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a 2-year research study by the J. David Gladstone Institutes, a non-profit biomedical research organization in San Francisco. The study aims to explore the underlying molecular mechanisms by which reducing levels of the tau protein can prevent or diminish excitation/inhibition imbalance and network hyperexcitability in the brain. This imbalance has been observed in various...
This Project Grant award, with a total funding amount of $130,302.00, was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The award, with an effective date of July 15, 2025 and an ultimate completion date of March 31, 2030, supports research at New York University (NYU) to investigate the molecular and functional impacts of pathological tau accumulation in basal forebrain cholinergic neurons and its consequences for Alzheimer's...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $784,596 to Northeastern University to conduct comprehensive and cell type-specific proteogenomic profiling of aberrant and mis-processed proteins in Alzheimer's disease (AD) and tauopathy models. The project aims to substantially expand understanding of protein dysfunctions in AD by applying state-of-the-art proteomic methods paired with proteogenomics across multiple brain regions, AD stages,...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $437,250 to the University of California, San Diego (UCSD) to develop new tools for imaging the tau protein and its phase transitions in living cells. The research aims to map and measure tau in its soluble, liquid-liquid phase separation, and liquid-solid phase separation forms, which is a critical limitation in the field. The project will leverage a peptide-based probe and...