The University of Alabama in Huntsville received a $875,994 project grant award from the National Institutes of Health National Institute of Neurological Disorders and Stroke to fund research exploring the role of the P75 neurotrophin receptor in dopaminergic neurodegeneration induced by oxidative stress. This three-year grant, awarded September 15, 2022 under the NIH's Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), will support investigations...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $163,750.00 to The Johns Hopkins University to conduct research on novel small molecule enhancers that can boost the activity of the glucocerebrosidase 1 (GBA1) enzyme. The research aims to identify promising drug candidates that can treat Parkinson's disease (PD) and...
The University of Alabama at Birmingham (UAB) received a $816,750 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The grant, titled "POLY(ADP-RIBOSE)-DEPENDENT TDP-43 PATHOLOGY IN OXIDATIVE STRESS (R21)," aims to study the mechanisms by which the TDP-43 protein accumulates in the cytoplasm of neurons under oxidative stress conditions, which is a key pathological process in frontotemporal dementia (FTD) and other...
This $406,260 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program will fund research to understand the spread of alpha-synuclein aggregates, which is believed to be a key mechanism underlying the onset and progression of Parkinson's disease (PD) and related dementias. The research aims to use fluorescence lifetime imaging microscopy...
This $2,192,716 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) aims to understand the role of serine-129 phosphorylation in the aggregation and spreading of α-synuclein pathology associated with Parkinson's disease, dementia with Lewy bodies, and related synucleinopathies. The project leverages novel serine-129 phospho-deficient and...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $414,191 to Drexel University to investigate the relationship between the molecular structure of alpha-synuclein (α-syn) protein fibrils and the emergence of distinct neurological disorders like Lewy body dementia, Parkinson's disease, and multiple system atrophy. The...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is providing $647,116 to the Regents of the University of Michigan to characterize and target a novel pathway promoting Parkinson's disease (PD) and Parkinson's disease dementia (PDD). The funded research aims to investigate how the interaction between the protease tissue...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will provide $655,329 to Albert Einstein College of Medicine to investigate the role of the GPNMB gene in the pathogenesis of Parkinson's disease, Lewy body dementia, and related synucleinopathies. The 5-year research project aims to identify causal genetic variants that regulate GPNMB...
The National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) awarded a $7,704,350 Project Grant to The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania, for the research project "Mechanisms Underlying Heterogeneity of Cognitive Outcomes in Synucleinopathy". The project aims to understand why the same underlying pathology, namely inclusions of alpha-synuclein, varies widely in the pace and...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $799,127 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Baylor College of Medicine to develop oligomeric alpha-synuclein targeted nano scavengers as a theranostic (diagnostic and therapeutic) approach for Parkinson's disease. The project aims to fully establish the preclinical potential of this nano scavenger concept across the prodromal, early, and...