This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program is funding research to study the spread of alpha-synuclein aggregates in Parkinson's disease and related dementias. The $406,260 grant, awarded on July 5, 2024, will support live-cell fluorescence imaging studies to characterize the aggregation and propagation of alpha-synuclein in...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $655,329 federal Project Grant (CFDA 93.853) to the Albert Einstein College of Medicine to investigate the role of the GPNMB gene in the pathogenesis of Parkinson's disease, Lewy body dementia, and related synucleinopathies. The research aims to identify causal genetic variants that regulate GPNMB expression and determine how GPNMB function in microglia contributes to neurodegeneration and neuroinflammation. The...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $669,115 to Texas A&M University System Health Science Center (TAMU HSC) for a 5-year research project on understanding the mechanisms underlying Parkinson's disease (PD) pathology and identifying potential therapeutic strategies. The key objectives of the research...
This Project Grant award, issued by the National Institute of Neurological Disorders and Stroke (NINDS), provides $2,280,379.00 to the Regents of the University of Michigan to develop novel nanobody-based agents that can target pathogenic alpha-synuclein to block cell-to-cell transmission. The research project aims to address the critical need for reagents that can target intracellular alpha-synuclein, a key driver of Lewy body dementias such as Parkinson's disease with dementia and a...
This Project Grant award of $245,847.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award is funding research at Duke University to investigate the role of the Integrated Stress Response (ISR) pathway in dopamine neurons, and how it may impact the development and progression of Parkinson's disease. The study aims to examine ISR...
This federal Project Grant award, valued at $858,471.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research at the University of Pennsylvania to investigate the role of N-terminal acetylation in regulating alpha-synuclein stability, function, and therapeutic targeting for Parkinson's disease and related neurodegenerative...
This $475,475 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research at Beth Israel Deaconess Medical Center, Inc. (Bidmc) in Boston, Massachusetts. The goal of the award is to evaluate a small molecule inhibitor of the USP30 enzyme as a potential neuroprotective therapy for Parkinson's disease. The research will assess...
This $616,200 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders federal grant program (CFDA 93.853) will fund research to explore the role of neuromelanin accumulation in dopamine neurons and its effects on cellular physiology, neuroinflammation, and neurodegeneration in Parkinson's disease. The primary awardee, the Oklahoma Medical Research Foundation, will work with...
This $799,127 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to develop a novel nanoparticle "scavenger" agent that can bind to and clear oligomeric alpha-synuclein, a key pathological species implicated in Parkinson's disease. The research aims to establish the preclinical potential of this nanoparticle...
This federal Project Grant award, valued at $682,493.00 and granted by the National Institute of Neurological Disorders and Stroke (NINDS), supports research into the role of aberrant histone acetylation in the pathogenesis of Parkinson's disease and related synucleinopathies. The research, conducted by the Albert Einstein College of Medicine, aims to elucidate the functional significance of histone acetylation in the development of Parkinson's disease, Lewy body dementia, and related...