Project Grant R21NS140879
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is funding the development of a novel diagnostic assay for Parkinsonian tauopathies. The $446,991 award, made on Aug 7, 2025, supports the creation of aptamer-based ELISA assays to detect two tau peptides that can distinguish progressive supranuclear palsy (PSP) from corticobasal...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to develop a novel gene therapy approach to reduce neurotoxicity in Parkinson's disease. The $1,009,212 award to the Van Andel Research Institute in Grand Rapids, MI will fund pharmacodynamic, pharmacokinetic, and in vivo efficacy studies to enhance the activity of the...
- This federal Project Grant award of $476,643.00 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), supports research to study the neurophysiological basis of impaired gait in mouse models of Parkinson's disease. The key objectives are to examine how the dorsolateral striatum and substantia nigra pars reticulata, which are part of the basal ganglia, encode gait...
- This $616,200 Project Grant was awarded on February 1, 2025 by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research to explore the influence of neuromelanin, a dark pigment, on dopaminergic neurons in Parkinson's disease. The project aims to develop a novel mouse model that accumulates neuromelanin in dopamine neurons to study the resulting...
- This $475,475 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research at Beth Israel Deaconess Medical Center, Inc. (Bidmc) in Boston, Massachusetts. The goal of the award is to evaluate a small molecule inhibitor of the USP30 enzyme as a potential neuroprotective therapy for Parkinson's disease. The research will assess...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is providing $647,116 to the Regents of the University of Michigan to characterize and target a novel pathway promoting Parkinson's disease (PD) and Parkinson's disease dementia (PDD). The funded research aims to investigate how the interaction between the protease tissue...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will provide $2,723,954.00 to the University of Alabama at Birmingham (UAB) from June 1, 2025 to May 31, 2027. The grant supports research focused on understanding the effects of 14-3-3θ protein phosphorylation on vesicular transport and alpha-synuclein aggregation, which are key mechanisms...
- This federal Project Grant award of $140,690 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research to investigate the relationship between gamma oscillations in the motor network and dyskinesia (excessive movement) in Parkinson's disease patients. The goals are to use chronically implanted neurostimulators and wearable sensors...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to establish the role of alpha-synuclein-mediated membrane permeabilization in the spread of alpha-synuclein aggregates related to Parkinson's disease and related dementias. The $406,260 award to Purdue University will leverage fluorescence lifetime imaging microscopy...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $646,104 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the San Diego Biomedical Research Institute, a non-profit research organization. The grant supports research to investigate how neuroinflammation mediated by the interleukin-13 receptor signaling pathway may contribute to the selective loss of dopaminergic neurons in Parkinson's disease. The...
This federal Project Grant award of $460,563.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) is supporting research focused on developing a therapeutic intervention for Parkinson's disease. The key products or services being delivered include: Investigating the potential of the brain-specific chaperone protein ProSAAS as a therapeutic target for Parkinson's disease. The research aims to characterize ProSAAS's ability to limit the misfolding and promote the degradation of alpha-synuclein, a key pathological protein in Parkinson's. Experiments are evaluating the neuroprotective effects of ProSAAS overexpression in animal models, including when administered after the onset of motor deficits, to assess its potential therapeutic efficacy. The research is also exploring the feasibility of a genetically modified astrocytic cell transplantation approach as a means of delivering ProSAAS as a therapy. The award was made to the University of California, Los Angeles (UCLA) and the project has a period of performance from Aug 1, 2025 to Jul 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $460.6k | 7/31/25 |