Project Grant R21EY039463
- The National Eye Institute awarded The University of Chicago $582,115 on September 1, 2026, under the Vision Research program (CFDA 93.867) to investigate the role of lens connexins, cellular stress, and ionic imbalance in cataract formation. The research will define pathogenic mechanisms linking disruption of lens ionic homeostasis and formation of calcium-containing deposits to cataract development. The project utilizes human lens material, mutant mouse models, and in vitro systems to...
- The National Eye Institute awarded the University of North Texas Research and Innovation Division $564,489 on September 1, 2026, under the Vision Research program (CFDA 93.867) to conduct a large-scale epidemiological study examining occupational chemical and non-chemical exposures in relation to cataract risk. The project, titled "Cataract Risk and Occupational Exposures in Denmark," will extract data from established Danish health registers and apply validated job exposure matrices...
- The National Eye Institute awarded Vanderbilt University Medical Center $714,844 on September 1, 2026, under the Vision Research program (CFDA 93.867) to develop enabling technologies for pre-clinical and translational research using three-dimensional adult retina tissue culture. The award funds three technical aims: development of a custom scalable microfluidic platform integrated into air-liquid interface culture format to stabilize retinal tissue culture conditions and enable programmable...
- Federal Grant Award Summary Vanderbilt University Medical Center received a $481,250 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective June 1, 2025 through May 31, 2027. The award funds research investigating the molecular mechanisms by which mutations in the ADAMTS10 gene contribute to primary open-angle glaucoma (POAG), a leading cause of irreversible blindness. The research employs genetically modified mouse models carrying...
- The National Eye Institute awarded Duke University $629,520 on September 1, 2026, under the Vision Research program (CFDA 93.867) to investigate the structural and functional roles of the cyclic nucleotide-gated (CNG) channel and sodium/potassium/calcium exchanger (NCKX) complex in maintaining photoreceptor outer segment integrity. The research addresses how photoreceptor cells construct and sustain their light-sensitive outer segment organelles—modified cilia containing stacked disc membranes...
- The National Eye Institute awarded the University of Delaware $390,764 on September 1, 2026, under the Vision Research program (CFDA 93.867) to investigate regulatory networks controlling lens development and homeostasis as a means of understanding cataract pathology and prevention. The award funds research on transcriptional and post-transcriptional gene expression control mechanisms in lens development. The recipient will test a hypothesis that ELL2 (elongation factor for RNA polymerase II 2),...
- The National Eye Institute awarded The Schepens Eye Research Institute $858,394 on August 1, 2026, under the Vision Research program (CFDA 93.867) to develop multimodal foundation models for eye disease screening and prognosis. The research develops a vision-language foundation model trained on pairs of retinal images and clinical notes to enable downstream supervised models for detection and progression prediction of age-related macular degeneration, diabetic retinopathy, and glaucoma. The...
- The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded $693,423 to the University of Mississippi Medical Center on September 15, 2025, under the Vision Research program (CFDA 93.867) to develop and test a multivalent antibody cocktail for treating and preventing bacterial endophthalmitis. The funded research combines eight antibodies targeting virulence factors of Staphylococcus epidermidis, Staphylococcus aureus, and...
- The National Eye Institute awarded the University of Mississippi Medical Center $584,806 on August 1, 2026, under the Vision Research program (CFDA 93.867) to investigate mechanisms of adhesion and colonization during pneumococcal keratitis caused by Streptococcus pneumoniae. The research examines how pneumococcal bacteria regulate their outer polysaccharide capsule to adhere and colonize the corneal surface, and identifies a master regulatory system that controls bacterial survival and...
- The National Eye Institute awarded the University of Cincinnati Sponsored Research Services $445,500 on June 1, 2026, under the Vision Research program (CFDA 93.867) to conduct fate mapping and functional analysis of COL8A2-positive cells in corneal endothelial development and disease. The recipient will generate a tamoxifen-inducible COL8A2P2A-CREERT2 mouse line to enable temporal and tissue-specific labeling and manipulation of COL8A2-positive cells. In Aim 1, the team will use lineage tracing...
The National Eye Institute, part of the Department of Health and Human Services, awarded Vanderbilt University $435,875 on September 1, 2026, under the Vision Research program (CFDA 93.867) to investigate the mechanism of formation and cataractogenic properties of gamma-S-crystallin cleavage products. The research addresses cataract formation at the molecular level by elucidating how S-crystallin cleavage occurs in aging lenses and the functional consequences of such modification. The work comprises two primary aims: in Aim 1, proteomics analyses will determine the role of oxidative stress and mild thermal stress in producing S-crystallin cleavage and other cataractogenic signals; in Aim 2, the research will assess whether S-crystallin truncation products trigger protein aggregation and membrane binding of other lens crystallins. The long-term goal is to define mechanisms of cataract formation so that strategies to prevent or delay lens opacification can be developed. Performance occurs at Vanderbilt University's Nashville, Tennessee location. The project period extends from September 1, 2026, through August 31, 2028. This is a Project Grant, an assistance type offering direct funding for investigator-initiated research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $435.9k | 8/21/26 |