This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), supports research to investigate the role of cGMP signaling in glaucomatous neurodegeneration. The $526,841 award to Vanderbilt University Medical Center aims to elucidate how disrupted cGMP signaling in glaucoma impacts retinal astrocyte-vascular networks, leading to retinal ganglion cell (RGC) metabolic stress and axon degeneration. The research will utilize cell-specific...
This Project Grant award from the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) provides $246,000.00 in funding to The University of Texas Southwestern Medical Center to conduct research on the genetic basis and molecular mechanisms of early-onset glaucoma. The research will leverage a high-throughput and unbiased forward genetics pipeline to identify novel gene-phenotype associations related to this blinding disease. The project aims to advance the...
The National Eye Institute (NEI), through the Vision Research federal grant program (CFDA 93.867), awarded a $185,000 Project Grant to the University of North Texas Health Science Center at Fort Worth (UNTHSC). The funding will support a 2-year research project to discover novel disease-modifying therapies for the prevention and treatment of glaucoma. The research will employ computational pharmacological approaches to identify small molecule inhibitors that can interfere with the GREM1-BMP...
This federal Project Grant award of $679,159 from the National Eye Institute (NEI), under the NIH Vision Research program (CFDA 93.867), supports research to investigate the combined effects of aging and elevated intraocular pressure on the development of glaucoma and the retinal ganglion cell (RGC) transcriptome. The research aims to identify age- and glaucoma-specific transcriptomic changes, and determine how these changes are altered by in vivo transient epigenetic reprogramming using...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), will support research to investigate the molecular mechanisms underlying cell death caused by mutant myocilin misfolding in glaucoma. The $447,479 award to Georgia TECH Research Corp, which operates as the Office of Sponsored Programs, will fund a 5-year project to use a yeast model system to screen for gene targets and small molecule compounds that can rescue the cytotoxicity...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), provides $496,633 to Duke University to investigate the role of glypicans, specifically glypican-4 (GPC4), in regulating trabecular meshwork function, intraocular pressure, and the pathogenesis of glaucoma. The research aims to: 1) determine how increased GPC4 expression and secretion dysregulates Wnt and related signaling pathways to stimulate trabecular meshwork cell...
This Project Grant award, R21EY036552, was provided by the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867). The $191,095 award will support research at the University of North Texas Health Science Center at Fort Worth to investigate how metabolic changes in optic nerve head cells, particularly astrocytes and lamina cribrosa cells, contribute to the development of fibrosis in glaucoma. The key goals are to establish the role of the YAP/TAZ signaling...
This Project Grant award of $390,000 from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) supports research to assess the biomechanical and hydrodynamic effects of different drugs and treatments on modulating outflow facility in the eye. The goals are to improve understanding of intraocular pressure regulation mechanisms and dynamic outflow resistance, which could lead to new diagnostic and therapeutic biomarkers for glaucoma. Key activities include: Measuring...
This Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) provides $423,767 to the University of California, Davis to investigate the role of myeloid cells in the axon degeneration that occurs in glaucoma. The research aims to determine whether NAD+ boosting interventions, which have shown promise in preserving axons in previous traumatic injury models, also work in a less traumatic but more glaucoma-relevant model involving a rare...
This National Eye Institute (NEI) Vision Research (CFDA 93.867) Project Grant award of $387,428 supports research to investigate fundamental mechanisms driving optic nerve sensitivity to elevated intraocular pressure (IOP) in glaucoma. The 5-year project, led by the Research Foundation for the State University of New York (Upstate Medical Center), aims to determine how transient biomechanical strains on optic nerve head astrocytes may predispose them to glaucomatous dysfunction. The research...