Project Grant R21EY037409

Award Date 6/1/25
Completion Date 5/31/27
Dollars Obligated $481K
Federal Grant Program
93.867
Assistance Type
Project Grant
Place of Performance
Nashville, TN 37203, USA
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The research aims to: 1) Define the mechanism by which ADAMTS10 promotes TGF-β signaling, including the effects of glaucoma-causing ADAMTS10 mutations, and 2) Test the hypothesis that reduced TGF-β signaling resulting from these ADAMTS10 mutations leads to decreased optic nerve axon development in adult mice. Confirming these hypotheses could suggest that direct regulation of TGF-β signaling is a common feature of the ADAMTS family of proteins, potentially offering novel therapeutic approaches for glaucoma and other diseases.

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