Project Grant R21EY038948
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded $1,488,864 under the Vision Research program (CFDA 93.867) to Icahn School of Medicine at Mount Sinai for a three-year project (September 1, 2025 – June 30, 2028) investigating epigenetic regulation of meibomian glands in homeostasis and aging. The research aims to delineate how histone deacetylases (HDACs) and related epigenetic mechanisms control meibomian gland function and become dysregulated during aging, with...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded $431,750 to the University of California Irvine under the Vision Research program (CFDA 93.867) effective May 1, 2026, through April 30, 2028. This exploratory project grant funds research into the novel mechanisms underlying obstructive meibomian gland dysfunction (O-MGD), a condition characterized by altered lipid synthesis, duct dilation, and inflammatory disease of the eye's oil-secreting glands. The research deliverables...
- Federal Project Grant Award Summary The University of California, San Francisco received a $451,000 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded April 1, 2026, with completion targeted for March 31, 2028. The award funds research to identify autoantibodies associated with Sjögren's disease, particularly as it manifests in dry eye disease (DED), which disproportionately affects women. Using phage immunoprecipitation sequencing...
- Federal Grant Award Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded $495,229 to Augusta University Research Institute, Inc. on April 1, 2026, for a project titled "Molecular Subtyping of Dry Eye Disease: A Machine Learning Approach Using Tear Fluid Proteins." This three-year project (completion date February 28, 2029) addresses diagnostic and classification challenges in dry eye disease (DED), a prevalent ocular condition affecting...
- Federal Grant Award Summary Award Overview The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded a Project Grant of $175,293 to The Regents of the University of California, Berkeley, effective July 1, 2026, through February 28, 2031. This research initiative investigates the differential roles of transient receptor potential (TRP) cation channels—specifically TRPV1 and TRPA1—in modulating corneal mucin expression and bacterial defense mechanisms against...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded $545,948 to The Schepens Eye Research Institute, Inc. under the Vision Research program (CFDA 93.867) beginning April 1, 2026, through March 31, 2030. This Project Grant funds basic and translational research to understand the role of reactive astrocytes in glaucoma pathogenesis. The research deliverables will include scientific findings on how astrocytes in the optic nerve head respond to ocular hypertension,...
- Federal Project Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded a $900,600 Project Grant to The Regents of the University of California, San Francisco effective September 1, 2025, with completion targeted for August 31, 2027. This award funds research to advance understanding of corneal limbal stem cells (LSCs) during wound healing, with the objective of developing restorative treatments for corneal damage—a leading cause of...
- Federal Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded a $3.0 million Project Grant to the Doheny Eye Institute for research on the mechanobiology of retinal vascular inflammation and degeneration in diabetes. Commencing September 1, 2025, and concluding August 31, 2028, this grant funds fundamental and translational research investigating how mechanical stiffening of retinal blood vessels contributes to early-stage diabetic...
- Federal Project Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded $255,722 to the University of California, Berkeley, effective September 15, 2025, through August 31, 2027. This Project Grant funds research investigating the role and regulation of a distinct optic nerve microglia population in glaucomatous neuropathy. The research addresses mechanisms of retinal ganglion cell degeneration during ocular hypertension (OHT) by examining...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $638,625 Project Grant to the University of California, San Diego, effective August 1, 2025 through July 31, 2028, under the Vision Research program (CFDA 93.867). The award funds research to investigate the mechanisms of drusen formation in age-related macular degeneration (AMD), a leading cause of blindness affecting approximately 196 million people globally. The research employs a novel quartz crystal microbalance assay...
The National Eye Institute (NEI) awarded Scripps Research Institute a $506,000 Project Grant under the Vision Research program (CFDA 93.867) effective July 1, 2026, through June 30, 2028. The research project, "Mapping Lacrimal Gland Ionocyte RNA and Protein Secretion in Homeostasis and Inflammation," will deliver comprehensive molecular characterization of ionocyte cell populations within the lacrimal gland. The project involves isolating and transcriptomically profiling two distinct ionocyte subtypes (acinar and ductal) from both healthy mice and a Sjögren's syndrome disease model using advanced cell sorting technology and gene expression analysis to identify cell-type-specific molecular signatures and functional contributions to tear film production and ocular surface health. The research deliverables will advance understanding of lacrimal gland physiology and disease mechanisms relevant to tear composition disorders. The project specifically aims to define previously unrecognized functions of acinar ionocytes in ion homeostasis and to characterize how ionocyte gene expression patterns change in inflammatory disease states. These findings will contribute to the NEI's mission of preventing and treating vision diseases through innovative basic science research that enhances knowledge of the eye and visual system.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $506.0k | 7/1/26 |