Project Grant R01EY038397
- Federal Grant Award Summary Award Details: The National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), awarded Michigan State University $869,589 for a three-year project period (May 1, 2025 – April 30, 2028) to develop and validate a new animal model for studying evaporative dry eye disease (EDED). Research Products and Services: This project will establish EDED pathogenesis research capabilities through characterization of AWAT2 knockout (KO) mice, which...
- Federal Project Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded $451,000 to The Regents of the University of California, San Francisco on April 1, 2026, for a two-year research project concluding March 31, 2028. This project delivers advanced diagnostic research services through phage immunoprecipitation sequencing (PHIP-SEQ) analysis to identify autoantibodies associated with Sjögren's disease, particularly as it manifests as dry...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded $984,000 to The Regents of the University of California, San Francisco under the Vision Research program (CFDA 93.867) on September 30, 2025, for a planning and feasibility study on decentralized dry eye disease (DED) clinical trials. This R34 award, extending through September 29, 2027, will produce three primary deliverables: (1) development of a remote trial design framework enabling decentralized recruitment and study of...
- Federal Grant Award Summary Proteris Biotech, Inc. received a $321,904 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) effective August 1, 2025, through July 31, 2026. The award funds Phase I development of Clusterin (CLU), a novel therapeutic targeting epitheliopathy in dry eye disease. The company will conduct early-stage development activities at its Boston incubator facility, including non-Good Manufacturing Practice (GMP) stability...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $638,625 Project Grant to the University of California, San Diego, effective August 1, 2025 through July 31, 2028, under the Vision Research program (CFDA 93.867). The award funds research to investigate the mechanisms of drusen formation in age-related macular degeneration (AMD), a leading cause of blindness affecting approximately 196 million people globally. The research employs a novel quartz crystal microbalance assay...
- Federal Grant Award Summary The National Eye Institute (Vision Research program, CFDA 93.867) awarded Icahn School of Medicine at Mount Sinai a $1,488,864 Project Grant effective September 1, 2025 through June 30, 2028 to conduct research on the epigenetic regulation of the meibomian gland in homeostasis and aging. The research aims to delineate epigenetic mechanisms controlling meibomian gland homeostasis and dysregulated in aging, with the ultimate goal of developing therapeutic...
- Federal Grant Award Summary N'waii Inc. received a $697,600 Project Grant from the National Eye Institute (Vision Research program, CFDA 93.867) awarded on September 30, 2025, with completion targeted for September 29, 2026. The award funds the preclinical development and validation of a first-in-class mitochondrially targeted antioxidant therapeutic candidate designed to treat dry eye disease (DED). The company's proprietary small molecule demonstrates free radical scavenging potential and...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded New York University School of Medicine a $673,747 Vision Research project grant (CFDA 93.867) commencing June 1, 2025, and concluding May 31, 2030, to develop advanced optical imaging technology for early detection of age-related macular degeneration (AMD). The research focuses on advancing visible-to-near-infrared spanning optical coherence tomography (OCT) to achieve half-micron axial resolution for retinal imaging,...
- Federal Project Grant Award Summary The Doheny Eye Institute received a $3,046,866 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective September 1, 2025 through August 31, 2028. The award funds research on the mechanobiology of retinal vascular inflammation and degeneration in diabetic retinopathy (DR), a leading cause of vision loss in the working-age population. The research aims to deliver empirical findings and therapeutic insights...
- Federal Grant Award Summary The University of Missouri System received a $422,199 project grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) for the period July 1, 2025 through June 30, 2027. This research initiative focuses on identifying and targeting sex hormone receptors as a novel therapeutic approach to treat Meibomian Gland Dysfunction (MGD), the leading cause of dry eye disease worldwide. The project will investigate the crosstalk regulation...
Augusta University Research Institute, Inc. received a $495,229 Project Grant from the National Eye Institute under the Vision Research program (CFDA 93.867) beginning April 1, 2026 and concluding February 28, 2029. The primary deliverables include the development of molecular-based diagnostic subtypes for dry eye disease (DED) through advanced proteomic analysis and machine learning classification. The project will employ high-resolution liquid chromatography-tandem mass spectrometry (LC-MS/MS) to identify distinct molecular signatures in tear fluid that differentiate between aqueous-deficient dry eye and evaporative dry eye, thereby enabling classification of biologically relevant DED subtypes based on their underlying pathophysiological mechanisms. Additionally, the award funds the development of a point-of-care (POC) diagnostic tool utilizing multiplex immunoassays to enable real-time DED classification in clinical settings, as well as the creation of a publicly accessible tear proteomics database that integrates proteomic profiles with de-identified clinical data to support collaborative DED research. These deliverables are intended to transform dry eye disease management by enabling precision diagnostics and personalized treatment approaches, ultimately improving clinical outcomes for millions of affected individuals.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $495.2k | 4/3/26 |