Project Grant R01EY036095
- The National Eye Institute (NEI), under the U.S. Department of Health and Human Services, awarded a $321,904 Project Grant to Proteris Biotech, Inc. through the Vision Research federal grant program (CFDA 93.867). The award, spanning August 1, 2025 to July 31, 2026, will fund the early development of the natural tear protein clusterin (CLU) as a novel approach to treat dry eye disease. The research aims to conduct non-GMP stability analysis of the drug substance and product, as well as perform...
- This Project Grant award of $253,500.00 from the National Eye Institute (CFDA 93.867 - Vision Research) supports research by the Icahn School of Medicine at Mount Sinai to reconstruct a human blood-retina barrier and perfused vascular system. The goal is to investigate the role of apolipoprotein E (APOE) variants in age-related macular degeneration (AMD), a leading cause of vision loss. The researchers will optimize an in vitro human outer blood-retina barrier model to study AMD phenotypes and...
- The National Eye Institute (NEI) awarded a $862,580 Project Grant under the Vision Research program (CFDA 93.867) to The Regents of the University of Colorado, doing business as the University of Colorado-Denver. The grant, titled "The Aging Eyes Study: Mitochondrial Dysfunction as a Driver of Age-Related Vision Loss," will run from Sep 30, 2024 to Sep 29, 2026. The project aims to identify the role of mitochondrial function and genetics in the etiology of aging-related eye diseases,...
- The National Eye Institute (NEI) awarded a $673,747 Project Grant to New York University (NYU) for the "Visible-to-Near-Infrared Spanning Optical Coherence Tomography for Retinal Imaging at the Half-Micron Scale" research project under the NEI's Vision Research program (CFDA 93.867). The grant aims to develop advanced optical coherence tomography (OCT) techniques to enable more accurate in vivo measurement and localization of macular pigments and retinal pigment epithelium melanosomes,...
- This Project Grant award for $679,159 from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports research on in vivo epigenetic reprogramming of retinal ganglion cells (RGCs) in aging mice with glaucoma. The research aims to identify new therapeutic targets for glaucoma that can protect and rejuvenate RGCs, which are specifically targeted and damaged in this disease leading to vision loss. The 4-year project, awarded to The Schepens Eye...
- This federal Project Grant award from the National Eye Institute (NEI), part of the U.S. Department of Health and Human Services, will provide $562,660 to support the research project "NICOTINIC MODULATION OF DEEP LAYER SOMATOSTATIN INTERNEURONS FOR VISUAL CRITICAL PERIOD PLASTICITY" at the Icahn School of Medicine at Mount Sinai. The research aims to identify novel molecular and circuit targets for inducing neuromodulatory changes that mediate plasticity during the juvenile critical...
- The National Eye Institute (NEI) awarded a $448,250 project grant under their Vision Research federal grant program (CFDA 93.867) to The Research Foundation for the State University of New York, operating as Upstate Medical Center. The funding supports a 2-year research project titled "YKI-MITF-ECM Regulation of Eye Progenitor Epithelium Morphology" that will explore the role of the Hippo signaling pathway, the transcription factor MITF, and extracellular matrix in the development...
- This Project Grant award from the National Eye Institute (NEI), part of the U.S. Department of Health and Human Services, provides $385,000.00 in funding to Wayne State University to conduct research on genetic and glial support mechanisms in acute and chronic models of photoreceptor degeneration. The research aims to understand, prevent, and treat vision-related conditions and diseases, a focus area of NEI's Vision Research federal grant program (CFDA 93.867). The study will compare...
- The National Eye Institute (NEI), under the federal Vision Research grant program (CFDA 93.867), awarded a $595,302 project grant to Thomas Jefferson University, doing business as Sidney Kimmel Medical College, for the period of April 1, 2025 to March 31, 2030. The project aims to investigate how glucose and lactate support photoreceptor health and function in order to develop new treatment strategies to prevent vision loss. Specifically, the researchers will determine whether the retinal...
- The National Eye Institute (NEI), under the federal Vision Research grant program (CFDA 93.867), awarded a $144,200 Project Grant to Pennsylvania State University's Milton S. Hershey Medical Center. The grant, effective June 1, 2025 through November 30, 2027, will fund research to characterize the molecular mechanisms underlying increased levels of the protein REDD1 in the retina due to diabetes, and explore alternative intervention strategies for preventing retinal complications caused by...
The National Eye Institute (NEI) awarded a Project Grant to the Icahn School of Medicine at Mount Sinai for $744,432 on September 1, 2025 under the Vision Research federal grant program (CFDA 93.867). The grant supports a research project titled "Epigenetic Regulation of the Meibomian Gland in Homeostasis and Aging", which aims to delineate epigenetic mechanisms that control meibomian gland function and are dysregulated with aging. The research will investigate the role of histone deacetylases (HDACs) and the Hedgehog signaling pathway in regulating meibomian gland progenitor cell activity and maintenance, with the goal of understanding the epigenetic basis of meibomian gland dysfunction and evaporative dry eye disease in the aging population. The project is scheduled for completion on June 30, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $744.4k | 8/15/25 |