Project Grant K08EY039016
- Federal Project Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded a $900,600 Project Grant to The Regents of the University of California, San Francisco effective September 1, 2025, with completion targeted for August 31, 2027. This award funds research to advance understanding of corneal limbal stem cells (LSCs) during wound healing, with the objective of developing restorative treatments for corneal damage—a leading cause of...
- Federal Project Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded $255,722 to the University of California, Berkeley, effective September 15, 2025, through August 31, 2027. This Project Grant funds research investigating the role and regulation of a distinct optic nerve microglia population in glaucomatous neuropathy. The research addresses mechanisms of retinal ganglion cell degeneration during ocular hypertension (OHT) by examining...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded $431,750 to the University of California Irvine under the Vision Research program (CFDA 93.867) effective May 1, 2026, through April 30, 2028. This exploratory project grant funds research into the novel mechanisms underlying obstructive meibomian gland dysfunction (O-MGD), a condition characterized by altered lipid synthesis, duct dilation, and inflammatory disease of the eye's oil-secreting glands. The research deliverables...
- Federal Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded $143,031 to the University of California, Berkeley on December 4, 2025, with a completion date of May 31, 2028. This Project Grant funds computational modeling research investigating the role of spatial phase in the selectivity and invariance of neuronal responses in primary visual cortex (V1) and secondary visual cortex (V2) when processing intermediate-level features in...
- Federal Project Grant Award Summary Funding Agency: National Eye Institute (National Institutes of Health) Federal Program: Vision Research (CFDA 93.867) Award Amount: $624,743 Award Period: May 1, 2026 – April 30, 2030 Recipient: The Regents of the University of California, University of California, Berkeley UC Berkeley will conduct a four-year research project investigating the function and regulation of constitutive prostaglandin D2 (PGD2) and DP receptor signaling in retinal health and...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded the University of California, San Francisco a Project Grant of $737,998 effective July 1, 2026, through March 31, 2031, under the Vision Research program (CFDA 93.867). This award funds research to define area-specific cellular and circuit-level specialization in the human temporal cortex, with particular focus on identifying electrophysiological and synaptic features unique to excitatory neurons in the inferior...
- Federal Project Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded $1.43 million to the University of Oklahoma Health Sciences Center for a two-year research project (September 1, 2025 – August 31, 2027) investigating bacterial cloaking mechanisms in intraocular infections. The project addresses a critical public health challenge: bacterial eye infections that cause significant vision loss and blindness worldwide, particularly those...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded a $902,000 Project Grant to The Regents of the University of California, San Francisco under the Vision Research program (CFDA 93.867) effective September 1, 2025, through August 31, 2027. This award funds research to characterize a novel GLIS1 knockout (KO) mouse model of glaucoma, addressing the critical need for therapeutic strategies targeting neuroprotection in primary open-angle glaucoma (POAG), a leading cause of...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $255,340 Project Grant to The Regents of the University of California, San Francisco, effective May 1, 2026, through April 30, 2031, under the Vision Research program (CFDA 93.867). This award supports fundamental research into the development and regeneration of retinal ganglion cells in the vertebrate retina, with the goal of developing therapeutic strategies to restore vision in patients with glaucoma and other retinal...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $638,625 Project Grant to the University of California, San Diego, effective August 1, 2025 through July 31, 2028, under the Vision Research program (CFDA 93.867). The award funds research to investigate the mechanisms of drusen formation in age-related macular degeneration (AMD), a leading cause of blindness affecting approximately 196 million people globally. The research employs a novel quartz crystal microbalance assay...
Award Overview
The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded a Project Grant of $175,293 to The Regents of the University of California, Berkeley, effective July 1, 2026, through February 28, 2031. This research initiative investigates the differential roles of transient receptor potential (TRP) cation channels—specifically TRPV1 and TRPA1—in modulating corneal mucin expression and bacterial defense mechanisms against antimicrobial-resistant pathogens. Research Deliverables and Scope
The funded research addresses bacterial corneal infections caused by Pseudomonas aeruginosa and Staphylococcus aureus, which pose significant vision loss risks. The project will deliver molecular and biochemical analysis through two primary aims: (1) comparative transcriptional profiling using RNA sequencing and quantitative reverse transcription polymerase chain reaction (qRT-PCR) to assess TRP channel-mediated mucin expression in corneal epithelial and conjunctival cells, and (2) direct mucin quantification using mass spectrometry and confocal imaging to characterize ocular surface defenses. The research builds on the Fleiszig laboratory's three-decade research foundation identifying intrinsic corneal resistance factors, including cell membrane-associated and soluble mucins, antimicrobial peptides, and epithelial cell junction integrity. These deliverables advance NEI's mission to drive innovative research toward understanding and preventing vision diseases through enhanced knowledge of ocular defense mechanisms.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $175.3k | 6/30/26 |