Project Grant R21EY038912
- Federal Grant Award Summary West Virginia University Research Corporation received a $2.74 million Project Grant from the National Eye Institute (CFDA 93.867 – Vision Research) awarded September 15, 2025, with completion targeted for August 31, 2028. This research initiative addresses therapeutic development for photoreceptor outer segment (POS) defects associated with mutations in the Prominin-1 (PROM1) protein, a leading cause of inherited blindness for which no current treatments exist. The...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $421,136 Project Grant to the University of Maryland, College Park, effective August 1, 2025, through July 31, 2027, under the Vision Research program (CFDA 93.867). This award supports research into advanced wavefront shaping techniques designed to enable high-resolution fundus imaging in patients with ocular opacities—conditions affecting the cornea and lens that currently prevent effective posterior segment eye...
- Federal Grant Award Summary The National Eye Institute (Vision Research program, CFDA 93.867) awarded a $1,001,009 Project Grant to The Washington University, Office of Sponsored Research Services, effective July 1, 2025, through March 31, 2030. This research initiative, titled "Visual Feature Competition Between Central and Peripheral Retinal Pathways," will deliver fundamental scientific research investigating how visual signals for eye fixation and optokinetic reflex (OKR)...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded the University of Washington a $699,739 Project Grant effective August 1, 2025, through July 31, 2030, under the Vision Research program (CFDA 93.867). This award funds the development and application of novel chemical biology tools to investigate the molecular and cellular mechanisms underlying Transient Receptor Potential Vanilloid 1 (TRPV1) ion channel regulation by nerve growth factor (NGF). The research deliverables...
- Federal Project Grant Award Summary UC Berkeley received a $481,500 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective September 1, 2025 through August 31, 2026. The award funds research investigating the role of retinal waves in vascular development, specifically examining neural-glial-vascular signaling mechanisms critical to understanding vasculature development and potential therapeutic applications for conditions such as...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $740,700 Project Grant to The Trustees of Columbia University in the City of New York (Health Sciences Division) effective May 1, 2026 through April 30, 2028, under the Vision Research program (CFDA 93.867). The award supports research and development of small molecule Best1 ion channel activators to treat early-onset vitelliform macular dystrophy (also known as Best vitelliform macular dystrophy or BVMD), a genetic retinal...
- Federal Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded a $255,722 Project Grant to the University of California, Berkeley effective September 15, 2025, with completion targeted for August 31, 2027. This award funds research investigating the role and regulation of optic nerve microglia in glaucomatous neuropathy, specifically examining how lipoxin B4 (LXB4)—an endogenous neuroprotective lipid mediator produced by retinal...
- Federal Project Grant Award Summary Wayne State University received a $385,000 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective August 1, 2025 through July 31, 2029. The grant supports research investigating genetic and glial support mechanisms in acute and chronic models of photoreceptor degeneration. The research utilizes zebrafish models to compare transcriptional, cellular, and functional changes occurring during chronic and...
- Summary of Federal Project Grant Award The National Eye Institute (NEI) awarded a $422,125 Project Grant to the University of Miami's Office of Research Administration—School of Medicine on August 1, 2025, under the Vision Research program (CFDA 93.867) for a two-year project period concluding July 31, 2027. This award funds research investigating cholesterol homeostasis as a therapeutic target for demyelinating eye diseases, which are pathologies affecting the optic nerve that can cause...
- Federal Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded the University of California, Santa Barbara a $1.22M Project Grant effective September 15, 2025, through September 14, 2027. This award funds research to develop data-efficient methods for reconstructing natural images from functional magnetic resonance imaging (fMRI) data, thereby advancing visual neuroscience research capabilities. The project implements artificial...
West Virginia University Research Corporation received a $420,750 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective June 1, 2026 through May 31, 2028. The award funds development of a novel fluorescence-based pulse-chase labeling technique combined with super-resolution microscopy to track protein trafficking dynamics in mouse rod photoreceptor neurons. The research will utilize snap-tag technology to label nascent proteins and analyze their subcellular-level dynamics, with rhodopsin trafficking in rod photoreceptors serving as the model system for validating this innovative imaging methodology. The primary deliverables include technical validation of the snap-tag labeling approach in the mouse retina, quantitative super-resolution microscopy data characterizing protein trafficking mechanisms, and a validated research tool applicable to studying both fundamental and disease-relevant photoreceptor cell biology. This research addresses a critical knowledge gap regarding mammalian photoreceptor protein trafficking dynamics at the mechanistic level, with direct relevance to understanding protein mistrafficking mechanisms that precede photoreceptor cell death in blinding diseases. The work is conducted at the awardee's facility in Morgantown, West Virginia.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $420.8k | 6/3/26 |