Project Grant R61EY038305
- Federal Grant Award Summary Baylor College of Medicine received a $646,167 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded April 1, 2026, with a completion date of March 31, 2031. The research project investigates cellular and molecular mechanisms underlying age-related macular degeneration (AMD), the leading cause of vision loss in elderly populations. The study applies high-throughput functional genomics approaches to identify causal...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $638,625 Project Grant to the University of California, San Diego, effective August 1, 2025 through July 31, 2028, under the Vision Research program (CFDA 93.867). The award funds research to investigate the mechanisms of drusen formation in age-related macular degeneration (AMD), a leading cause of blindness affecting approximately 196 million people globally. The research employs a novel quartz crystal microbalance assay...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded New York University School of Medicine a $673,747 Vision Research project grant (CFDA 93.867) commencing June 1, 2025, and concluding May 31, 2030, to develop advanced optical imaging technology for early detection of age-related macular degeneration (AMD). The research focuses on advancing visible-to-near-infrared spanning optical coherence tomography (OCT) to achieve half-micron axial resolution for retinal imaging,...
- Federal Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded the University of Rochester a $1.31 million project grant effective July 1, 2025, through April 30, 2029, to investigate the pathogenic role of secretory phospholipase A2-IIA (PLA2G2A/sPLA2-IIA) in age-related macular degeneration (AMD). The research seeks to identify novel therapeutic targets for AMD, a leading cause of adult blindness with limited treatment options. The...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded Columbia University's Health Sciences Division a $156,302 Project Grant effective March 1, 2026, through August 31, 2028, under the Vision Research program (CFDA 93.867). This research project will deliver empirical findings and computational models advancing understanding of representational geometry in primate visual systems. The primary research products include characterization of how different cortical regions—specifically...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded The Methodist Hospital Research Institute a $1,029,472 Project Grant under the Vision Research program (CFDA 93.867) effective May 1, 2026, with completion targeted for April 30, 2028. This research initiative will develop and validate a novel cell therapy approach to treat age-related macular degeneration (AMD), the leading cause of irreversible blindness. The primary deliverables include the creation of a sustainable...
- Federal Grant Award Summary The National Eye Institute (Vision Research program, CFDA 93.867) awarded $3.56 million to The Research Foundation for the State University of New York on August 1, 2025, for a project extending through March 31, 2029. This Project Grant supports nutritional metabolomics research investigating the relationship between diet-derived metabolites and age-related macular degeneration (AMD) progression and retinal integrity in postmenopausal women. The research leverages...
- Federal Grant Award Summary Fannin Partners LLC received a $600,032 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) with an award date of September 1, 2025 and completion target of August 31, 2026. The award funds development of SCG3 raptamers—modified single-stranded DNA (ssDNA) aptamers designed as a novel targeted therapy for wet age-related macular degeneration (AMD). The project addresses a critical clinical need, as approximately 40% of...
- Federal Grant Award Summary This National Eye Institute (NEI) Vision Research program (CFDA 93.867) Project Grant award of $574,158 to Cleveland Clinic Lerner College of Medicine of Case Western Reserve University supports a five-year research initiative (September 1, 2025 through April 30, 2030) investigating the role of melanopsin in photoreceptor outer segment renewal. The research will produce empirical findings and mechanistic insights into how melanopsin, a photosensitive protein expressed...
- Federal Project Grant Award Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded Cleveland Clinic Lerner College of Medicine of Case Western Reserve University $615,928 on April 15, 2026, to investigate the mechanobiology of Bruch's membrane during aging and its implications for age-related macular degeneration (AMD). The primary research products will include spatial and temporal matrisome maps of the retinal pigment epithelium (RPE)/Bruch's...
The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded Columbia University's Health Sciences Division a Project Grant of $740,700 (Award Date: May 1, 2026; Completion Date: April 30, 2028) to develop small molecule drugs for early-onset vitelliform macular dystrophy (Best vitelliform macular dystrophy or BVMD). BVMD is a rare genetic eye disorder affecting approximately 60,000 patients in the United States that causes progressive vision loss and blindness by the fifth decade of life through damage to the macula and retinal pigment epithelium cells. The research addresses a significant unmet clinical need, as no approved treatments or ongoing clinical trials currently exist for this condition. Under this award, Columbia University will develop novel small molecule Best1 ion channel activators designed to overcome loss-of-function mutations responsible for the vast majority of BVMD cases. The research deliverables include identification and characterization of potent channel activators, determination of drug-binding mechanisms through single-particle cryogenic electron microscopy (cryo-EM) structural analysis, and chemical optimization of lead compounds. The rational therapeutic strategy aims to enhance channel function and restore chloride ion efflux capacity in retinal pigment epithelium cells, thereby preventing the accumulation of fluid and harmful waste products in the subretinal space that characterizes disease pathology.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $740.7k | 4/27/26 |