Project Grant R01EY037223
- This federal Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides funding of $147,486 to the University of Washington to conduct research on the role of parvalbumin-expressing neurons in primate cortical processing. The project aims to determine if these inhibitory neurons mediate gain control, a key neural computation, in the primate brain. Specifically, the research will use advanced viral genetic tools to optogenetically activate and inactivate...
- This federal Project Grant award of $428,349 from the National Eye Institute's Vision Research program (CFDA 93.867) supports research into the mechanistic assessment of retinal ganglion cell genesis. The award, with a performance period from July 1, 2025 to March 31, 2030, aims to investigate the shared gene regulatory network and downstream targets of the key transcription factors Atoh7, Pou4f2, and Isl1 that are required for proper retinal ganglion cell development. The research will be...
- This $240,750 federal Project Grant award from the National Eye Institute's Vision Research program (CFDA 93.867) aims to investigate the role of neural-glial-vascular signaling in the development of the eye's vasculature. The research has two main objectives: 1) Characterizing vasculature development and how it is altered in mice with modified retinal waves, using quantitative approaches and live imaging, and 2) Establishing the maturation of the glial-vascular unit through immunofluorescence...
- This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides funding to researchers at the University of California, San Francisco (UCSF) to study the neural mechanisms underlying visual processing and behavior after photoreceptor degeneration. The $237,588 award, spanning June 2025 through December 2027, will leverage the vertical optokinetic reflex (OKR) - a visual behavior that tracks global motion - to investigate how cone degeneration disrupts noise...
- This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides funding to Human Cell Co, a for-profit biotechnology research company, to develop a combination therapy for glaucoma. The award, totaling $360,897, will support research to determine if topical application of a nerve growth factor (NGF) mutein (HC201) in combination with oral nicotinamide (NAM) supplementation can more effectively improve retinal ganglion cell function compared to either treatment...
- This Project Grant award of $568,122.00, provided by the National Eye Institute (CFDA 93.867 - Vision Research), supports research at Baylor College of Medicine to unequivocally confirm the contribution of the neurovascular unit to glaucoma pathogenesis and identify endothelial cell-specific ligands with potential for neuroprotective therapy. The research aims to globally map ligands binding to ocular hypertension and healthy retinal cells, systematically identifying ocular...
- This Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (CFDA 93.853), supports research to understand how G protein-coupled receptors (GPCRs) regulate cellular functions in cardiomyocytes and neurons. The $396,031 award to the Augusta University Research Institute, Inc. will map the subcellular distribution of heterotrimeric G proteins, investigate how G proteins move upon receptor activation, and determine if G proteins are concentrated at specific...
- This Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) provides $127,861 to The Regents of the University of California, Berkeley to conduct research on the role and regulation of a distinct optic nerve microglia population in glaucomatous neuropathy. The research aims to elucidate how the lipoxin LXB4 regulates disease-associated microglia (DAM) in the optic nerve during ocular hypertension, a key mechanism in the neuroprotective effects of LXB4 against...
- This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $475,442 to the University of California, Los Angeles (UCLA) to conduct research focused on understanding the mechanisms underlying the ingestion of photoreceptor outer segment tips by the retinal pigment epithelium (RPE). The research aims to investigate the dynamic actin polymerization and trogocytosis process involved in this essential cellular function, as well as the daily timing of outer...
- This federal Project Grant award of $146,922 from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports research to investigate the role of ankyrins in mediating the development of synaptic connections between photoreceptors and their respective targets in the mammalian retina. The award to Baylor College of Medicine aims to elucidate the early molecular events that coordinate the selective wiring of photoreceptors, which is essential for...
This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) to the University of Washington provides $699,739 to develop new chemical biology tools to study how the inflammatory mediator nerve growth factor (NGF) regulates the trafficking of TRPV1 ion channels in living cells. The researchers will use genetic code expansion and rapid bio-orthogonal labeling techniques to directly visualize TRPV1 trafficking in response to NGF signaling and activation of the PI3K pathway. This research aims to elucidate the cellular and molecular mechanisms by which NGF promotes TRPV1 translocation to the plasma membrane, with the goal of better understanding the regulation of this important sensory ion channel. The award period runs from August 1, 2025 to July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $699.7k | 7/25/25 |